I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Hydroxychloroquine 100 mg tablet Chloroquine nazi Plaquenil sudden neck stiff neck pain The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. Prednisone comes as a tablet, a solution liquid, and a concentrated solution to take by mouth. Prednisone is usually taken with food one to four times a day or once every other day. Your doctor will probably tell you to take your doses of prednisone at certain times of day every day. The upside of prednisone is that it has the ability to control these flares by quickly alleviating the inflammation until other disease-modifying anti-rheumatic drugs DMARDs can take effect. While DMARDs like Plaquenil hydroxychloroquine and Arava leflunomide are more targeted in the control of the immune system, they are slower acting. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. What time should i take my prednisone and my plaquenil Best time to take plaquenil - HealthBoards, Prednisone MedlinePlus Drug Information How long for chloroquine to workPotential adverse effect with hydroxychloroquineMoa chloroquinePlaquenil hydroxychloroquine retinopathy I have been on plaquenil for 5 years and immune suppressants for three and this is the first time they have said anything about stopping when taking antibiotics. I would have asked, but the appointment was running super late and my blood pressure was way up by the time the dr came into see me. Stopping Plaquenil and Cellcept when on Antibiotics. Benefits and Risks of Prednisone - Verywell Health. Plaquenil and Prednisone. Compare Plaquenil vs Prednisone head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Plaquenil rated 6.8/10 vs Prednisone rated 7.7/10 in overall patient satisfaction. Taking Hydroxychloroquine with food and/or milk can help prevent stomach upset. If you miss a dose, take it as soon as you remember. If it is very near the time of the next dose, skip the missed dose and continue with your normal dosing schedule. Do not double dose at one time to catch up. Plaquenil should be stored away from light and moisture. When my wife was first diagnosed with PMR in May, 2016, she was put on 15mg Pred. A month later, she was told to take 400mg of plaquenil daily, with the understanding that plaquenil would replace prednisone eventually. This rheumy tried to get her down to 5mg six months later, which was a total mistake.