In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Plaquenil tb risk Plaquenil pupil change Lichen planus pigmentosus LPP is a rare form of lichen planus. It is characterized by oval or irregularly-shaped brown to gray-brown macules and patches on the skin. Areas that are exposed to sun such as the forehead, temples and neck are most commonly affected. Using multivariate logistic regression, we found that HCQ-induced pigmentation was independently associated with previous treatment with oral anticoagulants and/or antiplatelet agents and with higher blood HCQ concentration. Conclusions and Relevance Hydroxychloroquine-induced pigmentation is not a rare adverse effect of HCQ. Our data support the hypothesis that HCQ-induced pigmentation is secondary to ecchymosis or bruising. Dec 15, 2017 One such sign is hyperpigmentation, a sign from your skin that all is not well within your body. Hyperpigmentation is a dermatological condition when the getting discoloured and darkened in places. Skin, the largest organ of the human body, is a mirror of your health. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Plaquenil associated hyperpigmentation Hydroxychloroquine toxicity - EyeWiki, Hydroxychloroquine-Induced Pigmentation in Patients With. Hydroxychloroquine sulfatr interactionsAralen 150 mgPlaquenil and allergy medication interactionsPlaquenil spotting One such sign is hyperpigmentation, a sign from your skin that all is not well within your body. Hyperpigmentation is a dermatological condition when the getting discoloured and darkened in places. Health conditions that can cause hyperpigmentation. Health conditions that can cause hyperpigmentation.. Hydroxychloroquine-Associated Hyperpigmentation. - PubMed Central PMC. Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma. Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend. Drug-Induced Hyperpigmentation caused by Minocycline Minocin Antibiotic PLAQUENIL is indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults. Rheumatoid Arthritis. PLAQUENIL is indicated for the treatment of acute and chronic rheumatoid arthritis in adults. Ventricular arrhythmias and torsade de pointes have been reported with the use of hydroxychloroquine. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses, when associated with hypokalemia, or when used with other drugs known to prolong the QT interval.