The recommendation for first-line therapy for hypertension remains a beta blocker or diuretic given in a low dosage. A target blood pressure of less than 140/90 mm Hg is achieved in about 50 percent of patients treated with monotherapy; two or more agents from different pharmacologic classes are often needed to achieve adequate blood pressure control. Single-dose combination antihypertension therapy is an important option that combines efficacy of blood pressure reduction and a low side effect profile with convenient once-daily dosing to enhance compliance. Combination antihypertensives include combined agents from the following pharmacologic classes: diuretics and potassium-sparing diuretics, beta blockers and diuretics, angiotensin-converting enzyme (ACE) inhibitors and diuretics, angiotensin-II antagonists and diuretics, and calcium channel blockers and ACE inhibitors. The sixth report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VI)1 recommends that patients with hypertension and no comorbid illness begin antihypertensive drug therapy with a low dosage of a diuretic or beta blocker. Cost to the patient will be higher, depending on prescription filling fee Unfortunately, the degree of improvement in cardiovascular mortality is less than would have been expected based on epidemiologic data. This recommendation is supported by the results of a meta-analysis demonstrating that diuretics and beta blockers are the only agents shown to decrease the incidence of stroke and congestive heart failure in patients with hypertension.2 Diuretics administered in a low dosage have also been shown to decrease the incidence of coronary artery disease and total cardiovascular mortality.2Although the documented decreases in morbidity and mortality make adequate treatment of hypertension important, the National Health and Nutrition Examination Survey (NHANES) report3 showed that blood pressure is controlled to a level below 140/90 mm Hg in only 27 percent of patients diagnosed with hypertension. Cost to the patient will be higher, depending on prescription filling fee—Estimated cost to the pharmacist based on average wholesale prices (rounded to the nearest dollar) for 30 days of therapy at lowest given dosage in Red book. One postulated but not yet proven explanation is that the higher diuretic dosages used in the large trials cause relative hypokalemia, as well as increased serum lipid levels, insulin resistance and uric acid levels. Because monotherapy is effective in achieving this target goal in only about 50 percent of patients, treatment with two or more agents from different pharmacologic classes is often necessary to achieve adequate blood pressure control.4The rationale for using fixed-dose combination therapy is to obtain increased blood pressure control by employing two antihypertensive agents with different modes of action and to enhance compliance by using a single tablet that is taken once or twice daily.5 Using low doses of two different agents can also minimize the clinical and metabolic effects that occur with maximal dosages of the individual components of the combined tablet.6 These potential advantages are such that some investigators have recommended using combination antihypertensive therapy as initial treatment, particularly in patients with target-organ damage or more severe initial levels of hypertension.7—Estimated cost to the pharmacist based on average wholesale prices (rounded to the nearest dollar) for 30 days of therapy at lowest given dosage in Red book. These adverse metabolic effects counteract the positive cardiovascular benefits of blood pressure reduction. Losartan is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure may reduce the risk of strokes and heart attacks. Losartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to tighten. A lower blood pressure will increase the supply of the blood and oxygen to the heart. Valacyclovir what is it used for How can i buy phenergan Viagra without headache Xenical 120mg capsules Cozaar Losartan is a good blood pressure-lowering medicine that protects kidney function like an ACE inhibitor, but with fewer side effects. Lopressor metoprolol. Dec 18, 2009. To compare the effect of metoprolol and losartan on postinfarction remodeling, the LAD was ligated in rats. MI progressively decreased systolic. Metoprolol vertraagt de hartslag, verlaagt de bloeddruk en vermindert de zuurstofbehoefte van het hart. Het wordt onder meer gebruikt bij hoge bloeddruk. If you subscribe to any of our print newsletters and have never activated your online account, please activate your account below for online access. By activating your account, you will create a login and password. Heart failure is usually associated with left ventricular dysfunction. According to recent guidelines, patients with a left ventricular ejection fraction (LVEF) ≤40% are considered to have heart failure with reduced ejection fraction (HFr EF) or systolic heart failure. Patients with a LVEF ≥50% and symptoms of heart failure are considered to have heart failure with preserved ejection fraction (HFp EF) or diastolic heart failure; there is little evidence that drug treatment improves clinical outcomes in these patients.1,2 The treatment of acute heart failure is not included here. ACE INHIBITORS — All patients with heart failure with reduced ejection fraction should receive an angiotensin-converting enzyme (ACE) inhibitor. These drugs improve symptoms (generally over 4-12 weeks), decrease the incidence of hospitalization, and prolong survival in patients with heart failure. Dosage – ACE inhibitors should be started at low doses and titrated to the highest tolerated dose, targeting the maximum daily dosages listed in Table 1. Cautions – ACE inhibitors should be used cautiously in patients with systolic blood pressure 5.0 m Eq/L, or bilateral renal artery stenosis. Metoprolol losartan Having surgery? Here's how to manage your medications., Divergent Effects of Losartan and Metoprolol on Cardiac Remodeling. Fluconazole ear dropsBuy dapoxetine canadaMetformin er priceKamagra sildenafil citrate 100mgCialis how often I have been on atenolol and recently switched, perhaps unwisely at my own request, to metoprolol. THe above information about valsartan and losartan seems contrary to. Losartan and metoprolol - MedHelp. Metoprolol Apotheek.nl. Losartan oral and metoprolol succinate oral Drug.. A multicentre, randomised, double-blind, comparative study of antihypertensive efficacy and safety of losartan and metoprolol was carried out in. 77 patients with. Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Demarco on can i take metoprolol with losartan These are two different classes of. Compare Losartan vs Metoprolol head-to-head for uses, ratings, cost, side effects, interactions and more. Losartan rated 5.4/10 vs Metoprolol rated 6.6/10.