Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Plaquenil pregnancy sjogren's Hydroxychloroquine histamine Can plaquenil cause bad teeth Does hydroxychloroquine thin blood Nothing safer Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not necessarily by suppressing immunity. Is there a drug that I can. Is there a drug that I can take to replace plaquenil? Asked by tanner01 Updated 5 April 2018 Topics plaquenil, rheumatoid arthritis, methotrexate. I take methotrexate also but the plaquenil messed with my vision and I had to quit taking it. I been treated for ra for 19 yrs. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Substitutes for plaquenil Alternatives to Plaquenil DailyStrength, Is there a drug that I can take to replace plaquenil? Plaquenil antimalarial drug Plaquenil rated 6.8/10 in overall patient satisfaction. Compare Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Plaquenil Compared to Alternatives - Plaquenil Compared to Alternatives -. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. Natural" alternative to Plaquenil. - HealthBoards. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. The alternative to Plaquenil is a slightly different anti malarial called Quinacrine. Plaquenil replaced Quinacrine formerly called Atabrine for anti malarial prophylaxis so now the Quinacrine has to be made up into pills or gel capsules by a compounding pharmacy. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects.