Retinal toxicity associated with hydroxychloroquine and chloroquine

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  1. sexoboi New Member

    Retinal toxicity associated with hydroxychloroquine and chloroquine


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. Unfortunately, the retinal damage from these medications is largely irreversible, so it is critical to detect early retinal toxicity in the hopes of limiting the extent of visual loss. Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. The Risk of Retinal Toxicity with Plaquenil. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Retinal toxicity associated with hydroxychloroquine and chloroquine

    Recommendations on Screening for Chloroquine and., Retinal toxicity associated with chronic exposure to.

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  5. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    CLINICAL SCIENCES Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine Risk Factors, Screening, and Progression Despite Cessation of Therapy Patient B shows a less severe stage of toxicity with small islands of retinal damage in the areas 5° to 15° from the fovea. CONCLUSION. Chloroquine or hydroxychloroquine can cause retinal dysfunction detectable using mfERG before toxicity is clinically apparent. Quinine is an antimalarial associated with a distinct toxicity from that of chloroquine and hydroxychloroquine. Quinine is used for benign nocturnal muscle cramps and may cause toxicity with acute overdose.

     
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    I have been on the plaquenil 200 mgm for about 4 months now. Can you just stop taking plaquenil or do you have to wean off. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus What will happen if you stop taking plaquenil - Answers
     
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    Hydroxychloroquine - Side Effects, Dosage, Interactions. Nov 09, 2018 Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine is also used.

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    Hydroxychloroquine C18H26ClN3O - PubChem Hydroxychloroquine C18H26ClN3O CID 3652 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities.

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