Systemic medications reach the cornea through the tear film, aqueous humor and limbal vasculature. Acute onset of halos and glare: Bilateral corneal epithelail edema with cystic eruptions-atypical presentation of amiodarone keratopathy. Access from the tear film leads to deposition in the epithelium, from the limbal vasculature into the stroma, and from the aqueous into the endothelium, epithelium and stroma. Is uti a side effect of hydroxychloroquine Plaquenil oral mucosa Plaquenil and breastfeeding If cornea verticillata is associated with a drug that is known to produce retinal toxicities—most notably hydroxychloroquine, chloroquine, chlorpromazine, and tamoxifen—patients should be routinely monitored with automated visual fields plus spectral-domain optical coherence tomography SD OCT. The. A number of systemic drugs induce corneal epithelial changes characterized by deposits that might present as a vortex keratopathy described also as whorled or verticillate; thus, the term cornea verticillata or a diffuse corneal haze, punctate keratopathy, or crystalline precipitates. Cornea verticillata is often caused by the use of certain systemic medications, the most common of which include amiodarone, chloroquine, hydroxychloroquine, indomethacin, and phenothiazenes. Cornea verticillata can also be seen in the sphingolipidosis, Fabry disease. Read the related case report for more information on cornea verticillata It is, however, important to recognize these associations and to openly communicate your concerns with the primary care physician or specialist who prescribed the systemic drug, as they can be a precursor to lens, optic nerve or retinal changes that can cause permanent and serious vision impairment. Visual function and adverse ocular effects in patients with amiodarone medication. Fortunately, these corneal abnormalities usually are not visually debilitating or permanent. Cornea verticillata chloroquine When ‘Collateral Damage’ Strikes the Cornea, Drug-induced corneal epithelial changes - ScienceDirect Plaquenil getting immuneAralen online gamesPlaquenil overdoseAdverse effects of hydroxychloroquine sulfateChloroquine dose in tropical splenomegaly This video shows a cornea with amiodarone verticillata deposits. You can see these as a whorl pattern – the entity is also called whorl keratopathy or hurricane keratopathy. These deposits are benign, difficult to see, and rarely if ever have any visual significance. Drugs that can cause this pattern CACTI Mneumonic chloroquine, amiodarone, chlorpromazine, tamoxifen, Amiodarone Verticillata - Whorl Keratopathy Video -. Cornea verticillata - Ophthalmology. Does Patient with Lupus Have Plaquenil Retinopathy?. Disease Entity Cornea verticillata also called vortex keratopathy, whorl keratopathy, or Fleischer vortex describes a whorl-like pattern of golden brown or gray opacities in the cornea. Cornea verticillata, also called vortex keratopathy or whorl keratopathy, is a condition characterised by corneal deposits at the level of the basal epithelium forming a faint golden-brown whorl pattern. It is seen in Fabry disease or in case of prolonged amiodarone intake. Causes. Amiodarone Fabry’s disease Chloroquine Hydroxychloroquine Indomethacin. Chloroquine keratopathy as an example of drug-induced phospholipidosis contribution to the pathogenesis of cornea verticillata author's transl. Article in German Seiler KU, Thiel HJ, Wassermann O.