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    IV: 400 mg IV every 12 hours Oral: 500 mg orally every 12 hours Duration of therapy: 60 days Comments: -Therapy should be started as soon as possible after suspected/confirmed exposure. Use: For treatment of inhalational anthrax (postexposure) to reduce incidence/progression of disease after exposure to aerosolized Bacillus anthracis US CDC recommendations: -IV: 400 mg IV every 8 hours -Oral: 500 mg orally every 12 hours Duration of Therapy: Postexposure prophylaxis for B anthracis infection: 60 days Systemic anthrax: -With possible/confirmed meningitis: At least 2 to 3 weeks or until patient is clinically stable (whichever is longer) -When meningitis has been excluded: At least 2 weeks or until patient is clinically stable (whichever is longer) -Patients exposed to aerosolized spores will require prophylaxis to complete an antimicrobial regimen of 60 days from onset of illness. Cutaneous anthrax without systemic involvement: -Bioterrorism-related cases: 60 days -Naturally acquired cases: 7 to 10 days Comments: -The preferred drug for pregnant women -Recommended as a preferred oral drug for postexposure prophylaxis and for the treatment of cutaneous anthrax without systemic involvement -Recommended as the preferred IV drug for the treatment of systemic anthrax -Recommended for all strains (regardless of penicillin susceptibility or if susceptibility unknown) when used for postexposure prophylaxis, systemic anthrax when meningitis has been excluded, or cutaneous anthrax without systemic involvement -Recommended for use with a protein synthesis inhibitor when used for systemic anthrax; the addition of a bactericidal beta-lactam is recommended with possible/confirmed meningitis. -Systemic anthrax includes anthrax meningitis, inhalation anthrax, injection anthrax, gastrointestinal anthrax, and cutaneous anthrax with systemic involvement, extensive edema, or lesions of the head or neck. -Current guidelines should be consulted for additional information. IV: 400 mg IV every 12 hours Oral: 500 mg orally every 12 hours Duration of therapy: 60 days Comments: -Therapy should be started as soon as possible after suspected/confirmed exposure. Use: For treatment of inhalational anthrax (postexposure) to reduce incidence/progression of disease after exposure to aerosolized Bacillus anthracis US CDC recommendations: -IV: 400 mg IV every 8 hours -Oral: 500 mg orally every 12 hours Duration of Therapy: Postexposure prophylaxis for B anthracis infection: 60 days Systemic anthrax: -With possible/confirmed meningitis: At least 2 to 3 weeks or until patient is clinically stable (whichever is longer) -When meningitis has been excluded: At least 2 weeks or until patient is clinically stable (whichever is longer) -Patients exposed to aerosolized spores will require prophylaxis to complete an antimicrobial regimen of 60 days from onset of illness. Cutaneous anthrax without systemic involvement: -Bioterrorism-related cases: 60 days -Naturally acquired cases: 7 to 10 days Comments: -The preferred drug for pregnant women -Recommended as a preferred oral drug for postexposure prophylaxis and for the treatment of cutaneous anthrax without systemic involvement -Recommended as the preferred IV drug for the treatment of systemic anthrax -Recommended for all strains (regardless of penicillin susceptibility or if susceptibility unknown) when used for postexposure prophylaxis, systemic anthrax when meningitis has been excluded, or cutaneous anthrax without systemic involvement -Recommended for use with a protein synthesis inhibitor when used for systemic anthrax; the addition of a bactericidal beta-lactam is recommended with possible/confirmed meningitis. -Systemic anthrax includes anthrax meningitis, inhalation anthrax, injection anthrax, gastrointestinal anthrax, and cutaneous anthrax with systemic involvement, extensive edema, or lesions of the head or neck. Ciprofloxacin Dosage Guide with Precautions - Cipro IV ciprofloxacin dose, indications, adverse effects, interactions. Ciprofloxacin Cipro - Side Effects, Dosage, Interactions.
     
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