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S FDA regulates the safety and efficacy of medications sold in U. are regulated for safety and efficacy by pharmaceutical/pharmacy regulatory authorities in other countries. To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more ESTRADIOL (es tra DYE ole) is an estrogen. It is mostly used as hormone replacement in menopausal women. It helps to treat hot flashes and prevent osteoporosis. It is also used to treat women with low estrogen levels or those who have had their ovaries removed. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. 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