Divalproex sodium is an anticonvulsant (antiseizure) drug. It is also used to treat mania and to help prevent migraine headaches. It is sold under multiple brand names in the United States, including Depacon, Depakene, Depakote, and Depakote sprinkle. Divalproex sodium is effective in the treatment of epilepsy, particularly for preventing simple, complex (petit mal), absence, mixed, and tonic-clonic (grand mal) seizures . Divalproex sodium is also used to treat the manic phase of bipolar disorder (also called manic-depressive disorder) in adults, and to prevent migraine headache in adults. Divalproex sodium is chemically compounded from sodium valproate and valproic acid in a 1:1 ratio. Divalproex sodium is thought to work by increasing the levels of a brain neurotransmitter called gamma-aminobutyric acid (GABA). Apo-Divalproex, Apo-Valproic Syrup, Depacon, Dom-Divalproex, Dom-Valproic Acid, Epilem (UK), Epilem Chrono (UK), Episenta (UK), Epival CR (UK), Epival ECT, Gen-Divalproex, Gen-Valproic-Cap, Novo-Divalproex, Novo-Valproic ECC, Nu-Divalproex, Nu-Valproic, Orlept (UK), PHL-Divalproex, PHL-Valproic Acid, PMS-Divalproex, PMS-Valproic Acid, Ratio-Valproic, Ratio-Valproic ECC, Sandoz Valproic valproate sodium Injection: 100 mg/ml in 5-ml vial Syrup: 250 mg/5 ml valproic acid Capsules (delayed-release): 125 mg, 250 mg, 500 mg Capsules (liquid-filled): 250 mg divalproex sodium Capsules (containing coated particles or sprinkles): 125 mg Tablets (enteric-coated, delayed-release): 125 mg, 250 mg, 500 mg Tablets (extended-release): 250 mg, 500 mg Complex partial seizures Adults and children older than age 10: Initially, 10 to 15 mg/kg/day P. Discontinue drug if multiorgan hypersensitivity reaction occurs. • Instruct patient to take with food to minimize GI upset. Simple or complex absence seizures Adults and children older than age 10: Initially, 15 mg/kg/day P. If hyperammonemia or hyperammonemic encephalopathy (unexplained lethargy and vomiting or changes in mental status) is suspected, measure ammonia level. Watch for diverse signs and symptoms of multiorgan hypersensitivity reaction, such as fever and rash associated with other organ system involvement (lymphadenopathy, hepatitis, liver function test abnormalities, hematologic abnormalities, pruritus, nephritis, oliguria, hepatorenal syndrome, arthralgia, and asthenia). • Monitor valproate blood level; therapeutic range is 50 to 100 mcg/ml. If daily dosage exceeds 250 mg, give in two divided doses. Mania associated with bipolar disorder Adults: Initially, 750 mg (divalproex or valproic acid delayed-release) P. Watch for seizures and suicidal behavior or ideation. Consider discontinuing drug if pancreatitis is diagnosed. • Assess CBC (including platelet count), prothrombin time, International Normalized Ratio, and liver function tests. May increase by 5 to 10 mg/kg/day q week until blood drug level is 50 to 100 mcg/ml or adverse reactions occur; don't exceed 60 mg/kg/day. If daily dosage exceeds 250 mg, give in two divided doses. Titrate rapidly to desired effect or trough level of 50 to 125 mcg/ml. Use cautiously in: • bleeding disorders, organic brain disease, bone marrow depression, renal impairment • posttraumatic seizures caused by head injury (use not recommended) • history of hepatic disease • elderly patients • pregnant or breastfeeding patients • children. Alcohol use: additive CNS depression Closely monitor neurologic status. May increase by 5 to 10 mg/kg/day at weekly intervals until therapeutic blood drug level is reached or adverse reactions occur; don't exceed 60 mg/kg/day. Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, bilirubin: increased levels Bleeding time: prolonged Ketone bodies: false-positive results Platelets, white blood cells: decreased counts Thyroid function tests: interference with results Drug-behaviors. Activated charcoal, cholestyramine: decreased valproate absorption Antiplatelet agents (including abciximab, aspirin and other nonsteroidal anti-inflammatory drugs, eptifibatide, tirofiban), cefamandole, cefoperazone, cefotetan, heparin, thrombolytics, warfarin: increased risk of bleeding Barbiturates, primidone: decreased metabolism and greater risk of toxicity of these drugs, decreased valproate efficacy Carbamazepine: increased carbamazepine blood level, decreased valproate blood level, poor seizure control Chlorpromazine: decreased valproate clearance and increased trough level Cimetidine: decreased valproate clearance Clonazepam: absence seizures in patients with history of these seizures CNS depressants (such as antihistamines and antidepressants, MAO inhibitors, opioid analgesics, sedative- hypnotics): additive CNS depression Diazepam: displacement of diazepam from binding site, inhibited diazepam metabolism Erythromycin, felbamate: increased valproate blood level, greater risk of toxicity Ethosuximide: inhibited ethosuximide metabolism Lamotrigine: decreased valproate blood level, increased lamotrigine blood level Phenytoin: increased phenytoin effects and risk of toxicity, decreased valproate effects Salicylates (large doses in children): increased valproate effects Topiramate: increased risk of hyperammonemia with and without encephalopathy and hypothermia Tricyclic antidepressants: increased blood levels of these drugs, greater risk of adverse reactions Zidovudine: decreased zidovudine clearance in patients with human immunodeficiency virus Drug-diagnostic tests. Infuse over 1 hour at a rate slower than 20 mg/minute. CNS: confusion, dizziness, headache, sedation, ataxia, paresthesia, asthenia, tremor, drowsiness, emotional lability, abnormal thinking, amnesia, hyperammonemic encephalopathy, suicidal behavior or ideation EENT: amblyopia, blurred vision, nystagmus, tinnitus, pharyngitis GI: nausea, vomiting, diarrhea, abdominal pain, dyspepsia, anorexia, pancreatitis Hematologic: leukopenia, thrombocytopenia Hepatic: hepatotoxicity Metabolic: hyperammonemia Musculoskeletal: back pain Respiratory: dyspnea Skin: rash, alopecia, bruising Other: abnormal taste, increased appetite, weight gain, flulike symptoms, infection, infusion site pain and reaction, multiorgan hypersensitivity reaction Drug-drug. Buy valtrex in canada Doxycycline kennel cough dosage Lasix kidney function Metoprolol forum Depakote is a brand name for Valproate, also known as Valproate semisodium. It's approved for treatment of epilepsy and bipolar disorder and has also been. Dashboard. Recently viewed. My Work. Notifications 0; Tasks. Other. Switch to desktop version · Log in. Navigation. Confluence Mobile. Popular; Blogs; Network. You can help Wikipedia by reading WikipediaHow to write Simple English pages, then. Depakote tablets are a mixture of sodium valproate and valproic acid. Divalproex sodium is also used to treat the manic phase of bipolar disorder (manic-depressive illness), and helps prevent migraine headaches. This medicine is available only with your doctor's prescription. Divalproex sodium affects chemicals in the body that may be involved in causing seizures. Divalproex sodium is used to treat various types of seizure disorders. Divalproex sodium is sometimes used together with other seizure medications. Divalproex sodium is also used to treat manic episodes related to bipolar disorder (manic depression), and to prevent migraine headaches. Divalproex sodium may also be used for purposes not listed in this medication guide. Divalproex sodium can cause liver failure that may be fatal, especially in children under age 2 and in people with liver problems caused by certain genetic disorders. You should not use divalproex sodium if you have liver disease, a urea cycle disorder, or a genetic disorder such as Alpers' disease or Alpers-Huttenlocher syndrome. Depakote wiki DIVALPROEX SODIUM EXTENDED-RELEASE - ORAL Depakote ER., Michigan Medicine Confluence Confluence Mobile Metformin news todayZoloft blood thinnerBuy genuine xenical onlineLamictal starter packsFluconazole resistance Jun 21, 2018. A side effect to monitor with Depakote is prolonged bleeding time - noting any bruising or spontaneous bleeding. Monitor Dilantin levels. Introduction to Pharmacology - Wikiversity. Valproate - Simple English Wikipedia, the free encyclopedia. Depakote - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol.. From Wikipedia. Depakene; Depakine; Depakote; Dipropyl Acetate; Divalproex; Divalproex Sodium. Depakote ERdivalproex sodium 10/2017 version. Prevent migraine headaches. It is sold under multiple brand names in the United States, including Depacon, Depakene, Depakote, and Depakote sprinkle. Brand Name Depakote ER, Depakote Sprinkles, Depakote obsolete, Depakote. Medically reviewed by on Oct 3, 2018 – Written by Cerner Multum.