Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil for sjogren& 39 Chloroquine cytotoxic Lupus myositis often affects the muscles of your neck, pelvis, thighs, shoulders and upper arms; difficulty in climbing stairs and getting up from a chair are early symptoms. Later symptoms may include difficulty lifting objects onto a shelf, lifting your arm to comb or brush your hair, getting out of the bath. Common side effects Nausea and diarrhea This can often can be combatted by taking Plaquenil with food or milk. Dizziness Precautions with this side effect Do not drive, use machinery. Cramps. Headache. Dry skin. Loss of appetite. Plaquenil “ Side Effects Dizzy, upset stomach, back pain and side pain, abdominal cramps, leg cramps, rapid heart rate, anxiety and body felt covered in bruises Before taking Plaquenil my only symptom. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Cramps and plaquenil Compare Plaquenil vs Chloroquine -, Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Why is the drug hydroxychloroquineAlternative for plaquenil QUOTE=DawnI have been on plaquenil for around 8 months or so but these leg cramps have just gotten worse and the ladies I work with told me to get calcium with magnesium. That would help out with the leg cramps but I am worried with all the meds that I take I am afraid that it might interact with the meds. Foot and leg cramps Arthritis Information. Hydroxychloroquine Sulfate Muscle Spasms Reports.. Plaquenil Oral Uses, Side Effects, Interactions.. Aug 18, 2009 Ginny, I had some very minor diarrhea, nausea, cramping for about a week when I started Plaquenil. Everyone is different, but for me, taking the med about 15 min. after eating, rather than before or with a meal, makes things much easier on my stomach, even for just Advil. Abdominal pain is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take medication Enbrel, and have Pain. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more.