Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Chloroquine resistant malaria meaning Plaquenil help rx Stopping plaquenil before pregnancy A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. If you are using Plaquenil, The Wellish Vision Institute recommends regular eye exams to help catch any change that may be subtly occurring. Symptoms of retinopathy to be aware of are blind spots in your central vision, distortion of objects, blurring, light flashes and sensitivity, as well as colors becoming distorted and difficulty seeing at. Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Plaquenil eye light sensitivity Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS, Plaquenil Las Vegas Diabetic Retinopathy Wellish Vision. Cumulative chloroquine dosagePharmacokinetics of chloroquine in ratsChloroquine ovarian cancer With Plaquenil Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. New Plaquenil Guidelines. Dry eyes, Sjogren’s and Plaquenil. -. Hi, I have just started on PLaquenil in March. My vision has been checked and it is good. My eyes have been so sensitive to light even indoors and see floaters which my Dr says is nothing to worry about. Has anyone else been very light sensitive from PLaquenil. I mostly lurk on here but have learned a lot. You guys are An eye pressure test may be used to rule out other eye diseases, such as glaucoma. Signs and symptoms of Fuchs’ dystrophy can be difficult to detect at first. You also might feel tenderness in your eye, along with pain that goes from your eye to your jaw, face, or head. And you may have blurry vision, unexplained tears, or notice that your eyes are especially sensitive to light. Anterior scleritis also may make the white of your eye look red, and you may see small bumps there.