Mechanism of action of hydroxychloroquine in diabetes

Discussion in 'Northwest Pharmacy' started by Northid, 28-Feb-2020.

  1. ordewlywerm New Member

    Mechanism of action of hydroxychloroquine in diabetes


    It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc.

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    Context Hydroxychloroquine, a commonly used antirheumatic medication, has hypoglycemic effects and may reduce the risk of diabetes mellitus. Objective To determine the association between hydroxychloroquine use and the incidence of self-reported diabetes in a cohort of patients with rheumatoid. The mechanisms of action of hydroxychloroquine and chloroquine remain under continuous study in modern molecular medicine 17,18 using advanced tools in computational biology 19, synthetic biology. Mechanism of Action of Hydroxychloroquine as an Antirheumatic Drug By Robert I. Fox The antimalarial agents chloroquine and hydroxychloroquine have been used widely for the treatment of rheumatoid arthritis and systemic lupus erythematosus.

    The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea.

    Mechanism of action of hydroxychloroquine in diabetes

    Reducing Risk of Type 2 Diabetes Hydroxychloroquine Use in., Mechanisms of action of hydroxychloroquine and chloroquine.

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  4. Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown. Malarial parasites invade human red blood cells.

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    A study of about 200 patients with a history of hydroxychloroquine retinopathy, including 36 Asian patients, found that the pericentral pattern occurred in half the Asian patients but only 2% of the white patients. 31 The mechanism for this finding is unclear, but because pericentral retinopathy spares the macula, it can be missed using standard screening methods. Hydroxychloroquine, an alkylated 4-aminoquinoline, is a hydroxylated form of chloroquine and has a biological mechanism of action similar to chloroquine’s. Hydroxychloroquine was originally developed as a safer alternative to chloroquine for the treatment of malaria and was later found to have antirheumatic and anti-inflammatory uses. Since HCQ is an immunomodulatory drug has an inhibitory and an immunomodulatory effect on T cells and interleukin 1 and interleukin 6 and type 1 diabetes is an autoimmune disease, a possible reduction in islet-cell autoimmunity by HCQ could be the underlying mechanism since our patient has longstanding type 1 diabetes with no insulin reserve and an effect on insulin resistance is less likely to be the underlying mechanism that led to the improvement in glycemic control Ben-Zvi et al. 2011.

     
  5. Romafon User

    This is not a list of all drugs or health problems that interact with chloroquine. Chloroquine And Hydroxychloroquine Toxicity - nih.gov Hydroxychloroquine Side Effects - Plaquenil Hydroxychloroquine - Side Effects, Dosage.
     
  6. rokt Well-Known Member

    , l’exposition au soleil est vivement déconseillée lorsqu’on est atteint de lupus. Allergie au soleil symptômes & traitements Creapharma Plaquenil et soleil - Terre- L'exposition au soleil Pourquoi et comment protéger sa.
     
  7. marihuana Guest

    Hydroxychloroquine for Sjögren Syndrome Symptoms Importance Primary Sjögren syndrome is a systemic autoimmune disease characterized by mouth and eye dryness, pain, and fatigue. Hydroxychloroquine is the most frequently prescribed immunosuppressant for the syndrome.

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