Chloroquine-resistant plasmodium falciparum

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  1. asdsee Moderator

    Chloroquine-resistant plasmodium falciparum

    Rapid diagnostic assays for Pf CRT mutations are already employed as surveillance tools for drug resistance. Here, we review recent field studies that support the central role of Pf CRT mutations in chloroquine resistance.

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    A diagnosis of chloroquine-resistant P. falciparum malaria was made and the resistance was graded as R III. 5 Although parenteral chloroquine was discussed, it was felt that this trial would further delay effective management. Therefore, after a baseline estimation of random blood sugar result 6.0 mmol/L, the patient was given quinine hydrochloride 600 mg IV every eight hours, diluted in 300 mL of 5% dextrose over a period of four hours. Introduction. Pregnant women have an increased prevalence of Plasmodium falciparum P. falciparum infection and parasitemias may be high. 1 They are particularly prone to hypoglycemia, acute pulmonary edema, hemolytic anemia, fetal distress, premature labor and stillbirth. 2 Although chloroquine is the treatment of choice in pregnant women, chloroquine-resistant strains of P. falciparum are. Mutant forms of PfCRT and complete association of the K76T marker with chloroquine-resistant Plasmodium falciparum parasites from different geographic regions Of 16 chloroquine-sensitive lines from geographically distant regions, all but 1 showed the “wild-type” PfCRT sequence of the sensitive HB3 parent in the genetic cross.

    Recognition of the value of chloroquine was delayed, and it was not brought forward until it was reevaluated in the United States and designated the drug of choice against malaria near the end of World War II [3]. These studies suggest chloroquine resistance arose in ⩾4 distinct geographic foci and substantiate an important role of immunity in the outcomes of resistant infections after chloroquine treatment. Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency Early in the 20th century, intense demands for an effective quinine substitute launched the discovery and evaluation of a series of organic compounds (beginning with methylene blue), which led to pamaquine and quinacrine after World War I and ultimately produced chloroquine in 1934 [1, 2].

    Chloroquine-resistant plasmodium falciparum

    On the Mechanism of Chloroquine Resistance in Plasmodium., Chloroquine-Resistant Plasmodium Falciparum Malaria in a Pregnant Woman.

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    • Chloroquine-Resistant Plasmodium Falciparum Is It Our..
    • Chloroquine-Resistant Malaria The Journal of Infectious..
    • Chloroquine Resistant Malaria –.

    Drug-resistant P. falciparum. Chloroquine-resistant P. falciparum first developed independently in three to four areas in Southeast Asia, Oceania, and South America in the late 1950s and early 1960s. Since then, chloroquine resistance has spread to nearly all areas of the world where falciparum malaria is transmitted. Chloroquine-resistant Plasmodium falciparum malaria is a major health problem, particularly in sub-Saharan Africa. Falciparum DNA and a genus-specific reverse primer which hybridizes with DNA from all 4 Plasmodium spp. that infect humans P. falciparum, P. vivax, P. ovale, and P. malariae. To perform this.

  4. a_p Well-Known Member

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Hydroxychloroquine Side Effects Common, Severe, Long Term. Cardiomyopathy Caused by Longterm Treatment with. Hydroxychloroquine-Induced Restrictive Cardiomyopathy in a.
  5. tsag2000 Well-Known Member

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    Hydroxychloroquine MedlinePlus Drug Information