It is a disabling and painful condition which can lead to substantial loss of mobility due to pain and joint destruction. I really liked the Arava, but I I am now on MTX and Simponi now. The disease is also systemic in that it often also affects many extra-articular tissues throughout the body including the skin, blood vessels, heart, lungs, and... I was on the Orencia when I was on the above two you mentioned. Plaquenil sjogren& 39 Plaquenil and wet macular degeneration Chloroquine sketchy Venus williams plaquenil Hi Polly, I'm on all 3. I am doing well enough to walk & participate in an exercise class 3 times a week. I get the occasional pain or flare, but I've gotten to a good place by taking all 3 meds. I take plaquenil daily, Arava/leflunomide on Tues & Fri's, and Methotrexate 8 on Sundays. And I go to an opthamologist twice a year, per my Dr's. Apr 13, 2005 The Combination of Leflunomide Arava and Methotrexate is Safe & Efficacious for the Treatment of Rheumatoid Arthritis April 13, 2005 By Arthritis Center Methotrexate MTX, an anti-metabolite that inhibits purine pathways, has been the hallmark of standard of care for many years in the treatment of rheumatoid arthritis RA. CHICAGO – Combination therapy with leflunomide and hydroxychloroquine met all goals for efficacy, safety, and tolerability among patients with primary Sjögren’s syndrome in a randomized, placebo-controlled pilot study, lending support to evidence suggesting the two drugs have additive benefits. The doctor then kept me on my plaquenil and added Leflunomide (Arava) to replace the methotrexate. I started out on the Plaquenil and Methotrexate oral and while my RA symptoms were reduced some, the methotrexate made me extremely ill for 2 days after I took each dose. Arava and plaquenil together Interactions between Arava Oral and leflunomide-warfarin, The Combination of Leflunomide Arava. - Arthritis Information Chloroquine transfection protocolPlaquenil for msPlaquenil and heart ratePlaquenil steroidsPlaquenil heart This study was designed to evaluate the efficacy of the combination of methotrexate and hydroxychloroquine with leflunomide in the treatment of active rheumatoid arthritis over a period of 12 weeks. A significant change in disease activity score was seen in both the groups at 6 and 12 weeks after initiating therapy with the investigative drugs. Evaluation of efficacy of combination of methotrexate and.. Leflunomide-hydroxychloroquine combo shows promise in primary Sjögren’s.. Leflunomide Side-effects, uses, time to work. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Vaccinations, warfarin, and corticosteroids are among the many products that may react with Arava. This eMedTV resource lists other drugs that may cause interactions with Arava and describes what may happen if these medications are taken together. I was diagnosed with RA 2 years ago. Started off taking methotrexate, plaquenil and a round of low dose prednisone. Did well until side affects of methtrexate became too much mostly nausea. My rheumatologist put me on arava and I've been doing well. Pain mostly hands, wrists, ankles & feet is mild to moderate but definitely manageable.