Prednisolone for horses

Discussion in 'International Pharmacy' started by NEOmancer, 22-Aug-2019.

  1. bossgs Guest

    Prednisolone for horses


    Applies to the following strengths: tebutate 20 mg/m L; sodium phosphate 20 mg/m L; 15 mg/5 m L; 5 mg; (as sodium phosphate) 5 mg/5 m L; sodium phosphate 15 mg/5 m L; (as sodium phosphate) 10 mg/5 m L; (as sodium phosphate) 20 mg/5 m L; (as sodium phosphate) 25 mg/5 m L; acetate 50 mg/m L; acetate 25 mg/m L; 10 mg; 15 mg; 30 mg; 5 mg/5 m L; acetate; sodium phosphate; (as acetate) 15 mg/5 m L Initial dose: 200 mg orally once a day for 1 week, then 80 mg orally every other day for 1 month Comments: -Exogenous corticosteroids suppress adrenocorticoid activity least when given at the time of maximal activity; consider time of maximal adrenal cortex activity (2 AM to 8 AM) when dosing. -Controlled clinical trials have shown corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, although they have not been shown to affect the natural history of the disease. Use: For the treatment of acute exacerbations of multiple sclerosis. Dosing should be individualized based on disease and patient response: Initial dose: 5 to 60 mg orally per day; may be give once a day or in divided doses Maintenance dose: Adjust or maintain initial dose until a satisfactory response is obtained; then, gradually in small decrements at appropriate intervals decrease to the lowest dose that maintains an adequate clinical response Comments: -Exogenous corticosteroids suppress adrenocorticoid activity the least when given at the time of maximal activity; consider time of maximal adrenal cortex activity (2 AM to 8 AM) when dosing. -Alternate day therapy may be considered in patients requiring long-term treatment; it may be necessary to return to a full suppressive daily dose in the event of acute flare-ups. Uses: As an anti-inflammatory or immunosuppressive agent when corticosteroid therapy is appropriate, such as treatment of certain allergic states; nervous system, neoplastic, or renal conditions; endocrine, rheumatologic, or hematologic disorders; collagen, dermatologic, ophthalmic, respiratory, or gastrointestinal diseases; specific infectious diseases or conditions related to organ transplantation. Dosing should be individualized based on disease and patient response: Initial dose: 5 to 60 mg orally per day; may be give once a day or in divided doses Maintenance dose: Adjust or maintain initial dose until a satisfactory response is obtained; then, gradually in small decrements at appropriate intervals decrease to the lowest dose that maintains an adequate clinical response Comments: -Exogenous corticosteroids suppress adrenocorticoid activity the least when given at the time of maximal activity; consider time of maximal adrenal cortex activity (2 AM to 8 AM) when dosing. Prednisolone is a synthetic corticosteroid with approximately four times the anti-inflammatory potency of hydrocortisone. Corticosteroids have an effect on practically every system of the body. They are important in normal protein, carbohydrate and fat metabolism, and for their role in controlling inflammation. They have both strong beneficial effects and a definite potential to cause negative side-effects. Prednisolone commonly is used in both small- and large-animal veterinary medicine. It may be given by injection, orally, ophthalmically, or topically. Preparations for topical use may include other active ingredients such as antibiotics, antifungals, or miticides.

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    Description. Prednisolone is a synthetic corticosteroid with effective anti-inflammatory properties. Because horses do not absorb oral prednisone well, some veterinarians prefer to use other corticosteroids or oral prednisolone which is more readily absorbed by the horse's system. Now, however, a study from England shows that at least one glucocorticoid---the commonly used drug prednisolone---does not appear to make horses more susceptible to laminitis. I seem to remember reading somewhere -- which, of course, makes it true - -- that horses to do not metabolize prednisolone to the active steroid.

    Company: Dominion Suspension USP 10 mg/m L For Veterinary Use Only DIN 00250376 For use in the treatment of ketosis in cattle: bursitis, arthritis and joint inflammations involving ligaments in horses, and dermatitis, inflammatory conditions of joints, and as supportive therapy in dogs. Milk taken from treated animals within 72 hours after the latest treatment must not be used in food. CATTLE: 100-200 mg (10-20 m L) HORSES: 100-200 mg (10-20 m L) DOGS: 10-30 mg (1-3 m L). Treated animals must not be slaughtered for use in food for at least 5 days after the latest treatment with this drug. NET CONTENTS: 100 m L DOMINION VETERINARY LABORATORIES LTD., Winnipeg, Manitoba NAC No.: 11810521 Every effort has been made to ensure the accuracy of the Prednisolone Acetate information published above. However, it remains the responsibility of the readers to familiarize themselves with the product information contained on the Canadian product label or package insert. Prednisolone is a glucocorticoid commonly used in horses, for more information on glucocorticoids. Recently it has been shown that a common form of this drug prednisone is not effective so the prednisolone form should be used. This article is a brief synopsis about the contraindications, toxic effects, dosages, and association drug rules that apply to prednisolone use in horses. Prior to its use the article on glucocorticoids in general should be reviewed. You have just read the introduction to one of our nearly 800 articles on horse care, diseases, and training. It includes a description of the contents of the unabridged version. As a guest you can purchase this article but better is to become a member and Join us at Horseadvice and take advantage of all the benefits we have to offer: Access to all the sites articles and discussions and posting questions and comments to the Discussion Boards. Recommended to those who wish to have full access to one of the finest equine resources anywhere and engage an equine veterinarian and experienced horsefolks with questions and discussions on all aspects of horses and horsemanship.

    Prednisolone for horses

    Prednisolone for Veterinary Use - Wedgewood Pharmacy, Prednisolone - The Horse Owner's Resource

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