Hydroxychloroquine overdose toxicokinetics and management

Discussion in 'Hydroxychloroquine Plaquenil' started by www.swetlo.ru, 29-Feb-2020.

  1. nunki XenForo Moderator

    Hydroxychloroquine overdose toxicokinetics and management


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

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    Plaquenil or hydroxychloroquine HCQ is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid The Risk of Retinal Toxicity with Plaquenil YOUR CREDIBLE SJÖGREN'S RESOURCE Hydroxychloroquine overdose is infrequently reported and the majority of recommendations come from the greater experience with chloroquine poisoning. We report two cases of massive hydroxychloroquine poisoning 20 g in each case, both of which received advanced cardiac life support and a treatment regimen consisting of sodium bicarbonate, adrenaline and potassium. Abstract Hydroxychloroquine poisoning has rarely been reported in the literature, with only 18 cases being found on searching the literature. In this paper, we report a case that occurred in Hong Kong, and we make recommendations for emergency management of hydroxychloroquine overdose based on our and other's experience.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Hydroxychloroquine overdose toxicokinetics and management

    New Screening Guidelines for Hydroxychloroquine Toxicity, Survival after Massive Hydroxychloroquine Overdose - N. Gunja.

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  4. Background The management and toxicokinetics of hydroxychloroquine overdose are poorly described. Case Report We report a case of an 18-year-old girl who ingested 20 g of hydroxychloroquine. She developed marked hypokalemia, hypotension, and ventricular tachyarrhythmias but survived with treatment including intubation, adrenaline infusion, high-dose diazepam, and aggressive potassium replacement.

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    Quick treatment of hypotension, gastric decontamination, continuous long-term cardiac monitoring, and treatment of arrhythmias are the cornerstones of hydroxychloroquine overdose management. Hydroxychloroquine is a 4-aminoquinoline derivative prepared by beta hydroxylation of chloroquine. It is used in the treatment of malaria, rheumatoid arthritis, and lupus erythematosus, and marketed under the name Plaquenil Sanofi Pharmaceuticals, New York, NY. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include IBM Watson Micromedex updated, Cerner Multum™ updated, Wolters Kluwer™ updated.

     
  5. valsh Well-Known Member

    Authors: Dr Anes Yang, Clinical Researcher, Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia; Dr Monisha Gupta, Senior Staff Specialist, Department of Dermatology, Liverpool Hospital, Sydney, NSW, Australia. It is a hydroxylated version of chloroquine, with a similar mechanism of action. DESETHYL CHLOROQUINE 1476-52-4 CAS 4298-14-0 Didesethyl Chloroquine - BOC Sciences Simultaneous Determination of Chloroquine and Its Metabolite Desethyl.
     
  6. Chromanon New Member

    Saturday was a week since I stopped taking Plaquenil, aka Hydroxychloroquine, per my doctor’s instructions, and I think I am going through some form of withdrawal. Migraine - Diagnosis and treatment - Mayo Clinic Plaquenil Side Effects on Your Eyes and Vision I have missed 2 days of my Plaquenil- I have questions!
     
  7. realprof Well-Known Member

    Hydroxychloroquine Latest News & Videos, Photos about. Hydroxychloroquine Latest Breaking News, Pictures, Videos, and Special Reports from The Economic Times. hydroxychloroquine Blogs, Comments and Archive News on

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