Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Hydroxychloroquine sulfate 200 mg pil Plaquenil retinopathy treatment Aralen injection Prednisone vs plaquenil Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Mechanism of Action Chloroquine exerts its antimalarial effects by preventing the polymerization of heme into hemozoin a food source for the malarial parasite. Chloroquine forms a drug-hemozoin complex, and this complex caps the polymerizing chain, thereby preventing additional polymerization. This medicine may add to the chance of getting some types of cancer. Talk with the doctor. Keep away from children. Accidental exposure may cause death. If a child takes chloroquine by accident, get medical help right away. If you are 65 or older, use chloroquine with care. You could have more side effects. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine mechanism of action cancer Chloroquine - FDA prescribing information, side effects and uses, Chloroquine - StatPearls - NCBI Bookshelf Act chloroquinePlaquenil cause low blood pressure An important mode of action of chloroquine and hydroxychloroquine is the interference of lysosomal activity and autophagy. Mechanisms of action of hydroxychloroquine and chloroquine.. Chloroquine Indications, Side Effects, Warnings -. Chloroquine - FDA prescribing information, side effects.. Mechanism of action of chloroquine. Entry into the parasitized RBCs; 1. Accumulation in food vacuole of the parasite- role of pH gradient chloroquine trapping Affects asexual cycle of plasmodium specie. Once administered, it has to enter site of action. It rapidly enters and gets concentrated in food vacuole, present within erythrocytes. Despite its clinical use for decades, the precise mechanism of action of MQ was not determined until recently; Wong et al. determined the mechanism of action of MQ and found that it inhibits. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine -sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth.