I've stopped Sulfa as I was experiencing a bad taste & smell, which may be caused by sulfa. After a while it wasn't as effective and I too was prescribed methotrexate alongside. I'm about to start MTX & am hoping that I wont have side effects with that! The side effects of the methotrexate for me were horrendous (chronic chest infections) and I'm now asthmatic as a result. Plaquenil immune system Can i take a multivitamin with plaquenil Plaquenil use and weight and maculopathy Combination hydroxychloroquine and sulfasalazine - does it work for any of you. Now adding sulfasalazine hydroxychloroquine. Content on HealthUnlocked does. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. Sulfasalazine also is available in an enteric-coated stomach-coated pill that helps prevent nausea and abdominal discomfort. Sun sensitivity of the skin can also be a a side effect. Those on sulfasalazine should use sunscreen SPF 15 or higher when outdoors and avoid prolonged exposure to sunlight. I had side effects from MTX, which largely wore off, but haven't had any problems with the Hydroxy or Sulpha. I refuse to take it now even if its my passport to biologic treatment. I started with MTX which worked, but not enough so the others were added in which has been better. Sulfasalazine vs plaquenil Treatment of rheumatoid arthritis with methotrexate and., Methotrexate, Plaquenil or Sulfasalazine Azulfidine. Can plaquenil cause muscle weakness Jan 01, 2006 Combination therapy was associated with significantly fewer withdrawals 8 vs. 29%; P = 0.0008 ; withdrawals as a result of lack of efficacy and adverse events were also lower in the group receiving combination therapy 8 vs. 25% compared with sulfasalazine alone. However, combination therapy was associated with more frequent adverse events, such as infection, gastrointestinal complaints, and cardiovascular disorders. Combination Therapy for Rheumatoid Arthritis in the Era of.. Sulfasalazine Azulfidine. Any success with plaquenil or sulfasalazine? PsoriaticArthritis. Hi Samantha, I am lucky that I didn't have any side effects from MTX and it did control my pain after a time, unfortunately I had to take other meds too like Plaquenil and later Cimzia injections to reduce the inflammation and the combination led to liver problems and I am now off MTX and in more pain but hoping that the Cimzia which is a biologic will kick in soon. If the plaquenil is helping and they say you need it, I'd take it - the side effects will go away. I've not had experience with sulfasalazine - but from what I've read, the side effects of that med are about the same as those of plaquenil. BTW - sulfasalazine is an anti-inflammatory. Sulfasalazine is a type of drug known as a disease-modifying anti-rheumatic drug DMARDmay be used on its own or with other drugs. Sulfasalazine changes the way your condition affects you, and reduces inflammation, pain and swelling in your joints.