It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Adverse effects of long term use of plaquenil Chloroquine diphosphate salt autophagy Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Effectively prevents and treats malaria, and treats a certain type of intestinal infection but can cause serious side effects in certain people. I have PMR, but to get me to try to taper steroids, the rheum started me on generic Plaquenil. My right thigh muscle hurts, and walking up stairs is an issue - I can do it, but it hurts. I am trying to think back to if this was an issue when I was not on the Plaquenil - I have been on it for 4-5 months now, so it's hard to remember. Just got back from my neurologist and I am officially a "zebra" - my extreme and fast developing proximal muscle weakness myopathy is from doesn't mean I don't have any muscle weakness from the scleroderma, but the crazy, out-of-control weakness was from Plaquenil. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. What type muscle weakness with plaquenil Hydroxychloroquine Plaquenil, Hydroxychloroquine - thigh muscle weakness? Chloroquine and proguanil boots pricePlaquenil sun sensitivity View detailed reports from patients taking Hydroxychloroquine Sulfate who experienced muscular weakness. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Hydroxychloroquine Sulfate Muscular Weakness Reports.. Confirmed Plaquenil Muscle Toxicity - Scleroderma - Inspire. Plaquenil and muscle weakness Lupus Forums at The Lupus Site. Plaquenil made me feel alot weaker, with actual increased muscle weakness but it was more all over not just the thighs. That could be associated with some inflammation going on. You could get a test from your rhumy to check for any inflammation in your muscles to rule it out. If you are ok there a neuro would be your best bet. This is a new question concerning an old post. Plaquenil and muscle pain. I thought that maybe my question had been answered when I read that Plaquenil was responsible for your muscle pain but, as I read on I realize it was not. I TOO have severe muscle pain and cramping in my legs. Only when trying to sleep. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.