It is often the first line of attack before other more aggressive therapies are added such as methotrexate or rituximab that have bigger impacts on the immune system. I had almost (but not quite) forgotten what these aches and pains feel like, but they're back…I am re-acquainting myself with those symptoms that it tames: the overall flu-like and feverish feeling -- aka malaise -- and joint pain." (Click here to read more). I had a similar experience when I stopped taking plaquenil. Chloroquin for aquarium What is a natural medicine to hydroxychloroquine Hydroxychloroquine generic Plaquenil is often prescribed off-label by doctors for Sjogren’s Syndrome patients despite the fact that it has never been approved by governing agencies like the FDA. I myself have taken hydroxychloroquine for several years. My understanding is that the rheumatologist thinks that plaquenil is synergistic with mycophenolate and the 2 have a better chance of halting the progression of the neuropathy, and the other current and possible impacts of Sjogren’s better than mycophenolate alone. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. My joint and muscle pain went up and my energy levels went down. No, but it did alleviate some of the symptoms and improve my quality of life. It was one of those situations where I didn't realize the medication was having such an impact until I stopped it. Hydroxychloroquine for sjogren's syndrome vs another drug Hydroxychloroquine Side-effects, uses, time to work, Mycophenolate mofetil with Plaquenil Mayo Clinic Connect Does plaquenil make you immunosuppressedThe best way to taper off plaquenilSubstitute for hydroxychloroquinePlaquenil for asthma ABSTRACTHydroxychloroquine is an immunomodulatory drug that has been used for 60 years to treat malaria and autoimmune diseases such as systemic lupus erythematosus and inflammatory arthritis, and potential new uses and benefits continue to emerge. Toxicity concerns have been addressed with updated prescribing recommendations. Hydroxychloroquine An old drug with new relevance.. Conquering Sjogren's. Sjogren's syndrome - Diagnosis and treatment - Mayo Clinic. New Treatment Guidelines for Sjo¨gren’s Disease 533 all methodology elements, including protocol worksheets, data extraction tables, and literature search terms. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. As a member of the Sjogren's Syndrome Foundation, I receive regular issues of their fantastic newsletter, The Moisture Seekers. Among other excellent articles, the latest issue addresses questions about one of the most commonly used drugs in the treatment of Sjogren's Syndrome Plaquenil.