It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Aralen tablets Ibuprofin and plaquenil The more common side effects of methotrexate can include nausea or vomiting. stomach pain or upset. diarrhea. hair loss. tiredness. dizziness. chills. headache. sores in your lungs. mouth sores. painful skin sores. bronchitis. fever. bruising more easily. increased risk of infection. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. I was on both medis for 15 years for mixed connective disease. I recently stopped methotrexate due to lungs involvement, my pulmonologist decided to put me on cellcept.i had no majors side effects but a metal taste when I first started. Make sure you have a chest X-ray yearly and periodic labs work. Good luck. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Side effects of plaquenil and methotrexate Compare Methotrexate vs Plaquenil -, Methotrexate Oral Route Side Effects - Mayo Clinic Buy canada hydroxychloroquine hcq I do know that plaquenil is generally considered the least invasive drug, generally prescribed as the first line of treatment. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. I never had any side-effects of dire consequence, but many on this forum have. Methotrexate or Plaquenil? DailyStrength. Methotrexate and plaquenil - @Kristinsaba1988.. Compare Plaquenil vs Methotrexate -. Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Find information about common, infrequent and rare side effects of Methotrexate Anti-Rheumatic Oral.