It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. 4 aminoquinolines chloroquine Benefit of plaquenil Hydroxychloroquine stops flu virus What concentration does plaquenil come in Mar 02, 2018 Hydroxychloroquine retinopathy becomes more likely the longer any individual is taking the medication. The disorder is rarely seen within the first five years of treatment, but becomes more common with a longer duration of use. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these photos. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Hydroxychloroquine maculopathy Hydroxychloroquine-related retinal toxicity Rheumatology., Bull's-eye maculopathy due to hydroxychloroquine toxicity ChloroquinEffects of stop taking plaquenilCan hydroxychloroquine cause staphylococcus aureus utiTinnitus chloroquinePlaquenil maculopathy risk May 24, 2019 The risk may also be higher with some doses of hydroxychloroquine, if you use hydroxychloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Call your doctor right away if you have any eyesight changes like blurred or foggy eyesight, trouble focusing or reading, or trouble seeing in dim light. Hydroxychloroquine Indications, Side Effects, Warnings.. Plaquenil Risk Calculators. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. May 02, 2018 A study of about 200 patients with a history of hydroxychloroquine retinopathy, including 36 Asian patients, found that the pericentral pattern occurred in half the Asian patients but only 2% of the white patients. 31 The mechanism for this finding is unclear, but because pericentral retinopathy spares the macula, it can be missed using standard screening methods. Hydroxychloroquine retinopathy. It is the prescribing doctor’s responsibility to ensure their patients are adequately screened and to act on the results of screening. A useful aide memoir for these guidelines for hydroxychloroquine is the 5 x 5 rule ideally keep dosage 5mg/kg/day and screen after five years of drug use. Hydroxychloroquine is a prescription drug. It comes as an oral tablet. Hydroxychloroquine is available as the brand-name drug Plaquenil. It’s also available in a generic version.