Plasmodium falciparum chloroquine resistance transporter

Discussion in 'Chloroquin' started by EVAMS, 19-Mar-2020.

  1. Kestrel User

    Plasmodium falciparum chloroquine resistance transporter


    This score cannot be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry.

    Plaquenil pharmacology Chloroquine toxicity eye Chloroquine tablets brand india

    Hide 10 20 30 40 50 mkfaskknnq knsskndery reldnlvqeg ngsrlgggsc lgkcahvfkl 60 70 80 90 100 ifkeikdnif iyilsiiyls vcvmnkifak rtlnkignys fvtsethnfi 110 120 130 140 150 cmimffivys lfgnkkgnsk erhrsfnlqf faismldacs vilafigltr 160 170 180 190 200 ttgniqsfvl qlsipinmff cflilryryh lynylgavii vvtialvemk 210 220 230 240 250 lsfetqeens iifnlvlisa lipvcfsnmt reivfkkyki dilrlnamvs 260 270 280 290 300. Chloroquine-resistant cells efflux chloroquine at 40 times the rate of chloroquine-sensitive cells; the related mutations trace back to transmembrane proteins of the digestive vacuole, including sets of critical mutations in the P. falciparum chloroquine resistance transporter PfCRT gene. Extrusion of chloroquine CQ from digestive vacuoles through the Plasmodium falciparum CQ resistance transporter PfCRT is essential to establish CQ resistance of the malaria parasite. However, the physiological relevance of PfCRT and how CQ-resistant PfCRT gains the ability to transport CQ remain unknown.

    This is known as the 'taxonomic identifier' or 'taxid'. This subsection of the Names and taxonomy section contains the taxonomic hierarchical classification lineage of the source organism. Cyclic redundancy and other checksums Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)) AF030694 Genomic DNA Translation: AAF26926.1AF233064 m RNA Translation: AAF60271.1AF233065 m RNA Translation: AAF60272.1AF233066 m RNA Translation: AAF60273.1AF233067 m RNA Translation: AAF60274.1AF233068 m RNA Translation: AAF60275.1AF495376 Genomic DNA Translation: AAO85506.1AF495377 Genomic DNA Translation: AAO85507.1AF495378 Genomic DNA Translation: AAO85508.1AY651315 m RNA Translation: AAU00067.1AF468006 m RNA Translation: AAL75580.1DQ156107 m RNA Translation: AAZ81606.1DQ156108 m RNA Translation: AAZ81607.1DQ156109 m RNA Translation: AAZ81608.1DQ533840 m RNA Translation: ABF82363.1AY254700 m RNA Translation: AAP79044.1AF030694 Genomic DNA Translation: AAF26926.1AF233064 m RNA Translation: AAF60271.1AF233065 m RNA Translation: AAF60272.1AF233066 m RNA Translation: AAF60273.1AF233067 m RNA Translation: AAF60274.1AF233068 m RNA Translation: AAF60275.1AF495376 Genomic DNA Translation: AAO85506.1AF495377 Genomic DNA Translation: AAO85507.1AF495378 Genomic DNA Translation: AAO85508.1AY651315 m RNA Translation: AAU00067.1AF468006 m RNA Translation: AAL75580.1DQ156107 m RNA Translation: AAZ81606.1DQ156108 m RNA Translation: AAZ81607.1DQ156109 m RNA Translation: AAZ81608.1DQ533840 m RNA Translation: ABF82363.1AY254700 m RNA Translation: AAP79044.1 This subsection of the 'Entry information' section provides a mnemonic identifier for a Uni Prot KB entry, but it is not a stable identifier. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'. This subsection of the Names and taxonomy section shows the unique identifier assigned by the NCBI to the source organism of the protein.

    Plasmodium falciparum chloroquine resistance transporter

    Plasmodium falciparum chloroquine resistance transporter is a., Chloroquine - Wikipedia

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  5. Sep 30, 2015 Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, are the major determinant of chloroquine resistance in this lethal human malaria parasite. Here, we describe P.

    • Mutations in the Plasmodium falciparum chloroquine resistance..
    • Plasmodium falciparum chloroquine resistance transporter..
    • Chloroquine Resistance in Plasmodium falciparum - microbewiki.

    Mutations in the “chloroquine resistance transporter” PfCRT are a major determinant of drug resistance in the malaria parasite Plasmodium falciparum. We have previously shown that mutant PfCRT transports the antimalarial drug chloroquine away from its target, whereas the wild-type form of PfCRT does not. A simple high-throughput method to detect Plasmodium falciparum single nucleotide polymorphisms in the dihydrofolate reductase, dihydropteroate synthase, and P. falciparum cloroquine resistance transporter genes using ploymerase chain reaction and enzyme linked immunosorbent assay-based technology. In addition to its utility in the diagnosis of malarial infection, PCR appeared to be a must for epidemiological surveys focused on Plasmodium falciparum with resistance to aminoquinolines, as assessed by the detection of point mutations in the P. falciparum chloroquine-resistance transporter pfcrt and P. falciparum multidrug-resistance.

     
  6. sergiooo Moderator

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Hydroxychloroquine - Side Effects, Dosage, Interactions. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses How is plaquenil hydroxychloroquine used to treat lupus?
     
  7. GetBest XenForo Moderator

    Chloroquine use in transfection. - Tissue and Cell Culture Chloroquine is an inhibitor of the lysosomal degradation of the DNA which is taken up by the cells, so as leelee said, transfection should have been successful, albeit at a slightly lower level than if you would have added the chloroquine. In my normal transfections, I never add chloroquine and get high efficiencies nevertheless.

    Chloroquine C18H26ClN3 - PubChem
     
  8. ZaRaZa New Member

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