Thus, they seem to have another, similar disorder that doctors call undifferentiated connective tissue disease. Although the word "undifferentiated" sounds vague, it describes a real problem. Plaquenil generic vomiting Drug treatment of chloroquine resistant malaria Stevens johnsons chloroquine Nifedipine and hydroxychloroquine Comment My rheumatologist prescribed Plaquenil for connective tissue disease lupus / RA symptoms with fibromyalgia. I've taken 200mg twice a day and have noticed definite improvements in mobility / joint stiffness and the rash on my nose / cheeks. With undifferentiated connective tissue disease, I had excruciating pain for more than a year. Joint and muscle pain, lung pain, numbness in fingers and toes, almost lost a finger, fluid in the lungs - I can't even remember all of the symptoms. Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes. This undifferentiated category is distinctly separate from another group of vague-sounding disorders called overlap syndromes. It does not mean that a doctor does not know what to call the condition, it just means that all or most of the clinical features (problems) traditionally seen in lupus or another connective tissue disease aren't present but some of those features are present. Plaquenil for connective tissue disease Lupus Overlap Diseases What are Common Diseases Associated., Connective Tissue Disease Symptoms Treatment & Prognosis. Plaquenil brown spotsIs plaquenil still available Undifferentiated connective tissue disease UCTD is a term suggested by LeRoy 30 years ago to denote autoimmune disease that does not meet criteria for established illnesses such as systemic lupus erythematosus, scleroderma, dermatomyositis, Sjogren’s syndrome, vasculitis, or rheumatoid arthritis. Undifferentiated Connective Tissue disease - Rheumatology Advisor. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Recently Diagnosed with Mixed Connective Tissue Disease. This is a reivew of how effective Plaquenil hydroxychloroquine sulfate is for Mixed connective tissue disease and for what kind of people. The study is created by eHealthMe from 35 Plaquenil users and is updated continuously. eHealthMe has been monitoring drugs and supplements since 2008. For Undifferentiated Connective Tissue Disease “I’ve been on and off Plaquenil for 13 years for Undifferentiated connective tissue disease UCTD. I have NEVER had a flare while on plaq. From my research, Plaquenil is one of the most gentle of the disease-modifying drugs, so it's less likely to leave you at risk of infection. One known serious side-effect that happens to something like 1 in 5,000 people after many years of use is that it can cause retinal deposits, which can affect vision.