Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine mechanism of action lupus How long will plaquenil stay in your system I'm on Plaquenil, and after the first week's GI upset, I have had no problems with it. Did you take yourself off Plaquenil, or did your doctor tell you to go off it? And as far as the vision issue goes, toxicity causing vision loss is very rare if you are on the right dose for your height and if you get regular eye exams. Retinal toxicity from Plaquenil is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Before treatment is initiated with Plaquenil, a complete ophthalmic examination should be performed to determine any baseline macular or retinal disease. Eyes affected by Plaquenil toxicity can be diagnosed based on one or more of several possible telltale presentations ranging from structural changes visible on imaging equipment to functional changes detectable via testing. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and eyesight New Plaquenil Guidelines, Medications that can Affect the Eye or Visual System Plaquenil withdrawal symptomsPlaquenil bull& 39 Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine - Side Effects, Dosage, Interactions.. How to Succeed in Plaquenil Screenings. Plaquenil eye problems Mayo Clinic Connect. Inability to move the eyes increased blinking or spasms of the eyelid joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs loss of hearing lower back or side pain noisy breathing painful or difficult urination red irritated eyes Plaquenil is a drug used to treat Rheumatoid Arthritis and Systemic Lupus Erythematosis. It is a very good drug and gives many patients significant relief from their symptoms. Plaquenil related eye complications are not common. Plaquenil can produce pigment changes in the macula of the retina. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.