Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Aralen phosphate cost What are some side effects of hydroxychloroquine Plaquenil related cardiomyopathy This is extremely important as Plaquenil can but it is rare cause eye damage. The first few years on the Plaquenil, my eye exams were every 6 months, but now it is just once a year. Take care, Fran. Dx Lupus, sjogren's, celiac, severe allergies. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. The most important affect of Plaquenil on your eye is to damage the retina at the back of your eye. Fortunately, this is very uncommon and generally only occurs in patients on high doses or patients with bad kidney function. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause eye damage Conditions Plaquenil-related Eye Problems Eugene Eye Care, Plaquenil Side Effects Common, Severe, Long Term - Chloroquine injection for malaria treatment Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Long-Term Side Effects of Plaquenil for Rheumatoid.. Plaquenil & Your Eyes. What can Hydroxychloroquine Plaquenil do to my eyes?. I am going blind because of the retinal atrophy due to the plaquenil Normally after you stop plaquenil your eyes will stay at the damage level that was caused to it, but in rare cases the damage will continue. Although rare, Plaquenil can cause significant toxicity to the eye with prolonged use. Also, Plaquenil may have various systemic side effects that are not related to the eyes. These too are rare and include nerve weakness, hallucinations, psoriasis and changes in hair color. The eye complications are the most serious and worrisome. Ocular toxicity from hydroxychloroquine may be seen in two distinct areas of the eye the cornea and the macula. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs.