Chloroquine phosphate autophagy

Discussion in 'Canadian Pharmacy' started by ForlY, 01-Mar-2020.

  1. kennelov New Member

    Chloroquine phosphate autophagy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. Chloroquine is an aminoquinoline that is an inhibitor of autophagy and has antimalarial and anticancer activities. 1,2,3 Chloroquine inhibits autophagosome-lysosome fusion in HeLa cells when used at a concentration of 100 µM. 1 It is active against the chloroquine-sensitive GC03 strain of P. falciparum IC 50 = 29.2 nM but has decreased activity against mutant pfcrt P. falciparum IC 50 s. Chloroquine phosphate, an old drug for the treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine phosphate autophagy

    Chloroquine Phosphate - WebMD, Chloroquine phosphate - Cayman Chemical

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  5. Mar 16, 2020 Is chloroquine a cure for coronavirus? Some scientists are touting the efficacy of the drug in preliminary studies, but are also noting that much more research needs to be done before confirming.

    • Is Chloroquine a Cure for Coronavirus? Scientists Say Maybe..
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    • Chloroquine Phosphate – Marine Fish Diseases and Treatment.

    Autophagy is involved in the pathophysiology of numerous diseases and its modulation is beneficial for the outcome of numerous specific diseases. Several lysosomal inhibitors such as bafilomycin A1 BafA1, protease inhibitors and chloroquine CQ, have been used interchangeably to block autophagy in in vitro experiments assuming that they all. Chloroquine phosphate 50-63-5 is an antimalarial drug. Inhibits autophagy in a variety of cell lines 1. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer 2. While there is considerable evidence for the efficacy and safety of chloroquine the mechanisms underlying the tumor suppressive actions of this drug remain elusive. Up until recently, inhibition of the late stage of autophagy was thought to be the major mechanism of chloroquine-mediated cancer cells death.

     
  6. veronikas Guest

    This article focuses upon hydroxychloroquine retinopathy. Chloroquine was originally used as an anti-malarial therapeutic. Hydroxychloroquine-Induced Retinal Toxicity - American. Will you have Retinal detachment with Plaquenil - eHealthMe Despite Plaquenil dosing recommendations, retinal toxicity.
     
  7. serg73 New Member

    Plaquenil Uses, Dosage & Side Effects - Apr 10, 2019 Plaquenil hydroxychloroquine belongs to a group of medicines called quinolines. Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

    Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.