Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Surgical chloroquine prep Marine chloroquine phosphate Hydroxychloroquine and beer Plaquenil is manufactured in only a 200 mg tablet The typical dosage is either 200 or 400 mg per day 200 mg daily puts anyone under 68 pounds at risk1 400 mg of Plaquenil daily puts anyone under 135 pounds at a higher risk for toxicity Therefore, 200mg of Plaquenil daily is going to be a safe dosage for virtually all adults13 Jan 05, 2020 Hydroxychloroquine retinopathy is most influenced by daily dose and duration of use. Risk for toxicity is less with 5.0 mg/kg real weight/day for hydroxychloroquine and 2.3 mg/kg real weight/day for chloroquine. Patients are at low risk during the first 5 years of treatment. The incidence of retinal toxicity is associated with the cumulative dose of the drug, increasing significantly beyond 1,000 g of HCQ. This cumulative dose is created when the common dose of 400 mg/day is used for 6.8 years. Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil dosage maculopathy Despite Plaquenil dosing recommendations, retinal toxicity., Hydroxychloroquine toxicity - EyeWiki Side effects hydroxychloroquine eyesHydroxychloroquine syrupChloroquine synthesis slideshare Typical starting dose is 800 mg. This is followed by 400 mg three times 6 hours after the first dose, 24 hours after the first dose, and 48 hours after the first dose. Hydroxychloroquine Side Effects, Dosage, Uses, and More. Retinal Physician - Hydroxychloroquine Maculopathy An.. Hydroxychloroquine An old drug with new relevance.. Hydroxychloroquine is typically prescribed at 200mg/day to 400 mg/day. Dosage should be based on ideal body weight, not actual body weight because the medication is not retained in fatty tissues. 3,4,9 A 200mg tablet is safe for all but the smallest patients. Dec 04, 2014 The AAO guidelines defined high-risk patients by any one of the following criteria HCQ treatment 5 years in duration, HCQ dose 6.5 mg/kg/day, significant renal or hepatic disease, preexisting maculopathy due to other etiology, age 60 years, obesity, or cumulative HCQ consumption of 1000 g. Any daily dose of greater than 400 mg and being prescribed a maintenance dose of more than 6.5 mg/kg/day may increase the likelihood 1. Duration of treatment Taking Plaquenil for more than 5 years and if the total amount taken by the patient reaches more than 1000 g may put the patient at risk for the toxicity 1.