Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Plaquenil and other medications Chloroquine raynauds Chloroquine is a potent pulmonary vasodilator that attenuates hypoxia-induced pulmonary hypertension. Br J Pharmacol. 2017;155-4172 pubmed publisher Choi J, Kim H, Bae Y, Cheong H. REP1 Modulates Autophagy and Macropinocytosis to Enhance Cancer Cell Survival. Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Chloroquine is an aminoquinoline that is an inhibitor of autophagy and has antimalarial and anticancer activities. 1,2,3 Chloroquine inhibits autophagosome-lysosome fusion in HeLa cells when used at a concentration of 100 µM. 1 It is active against the chloroquine-sensitive GC03 strain of P. falciparum IC 50 = 29.2 nM but has decreased activity against mutant pfcrt P. falciparum IC 50 s. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine diphosphate sigma Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika., Chloroquine phosphate C18H32ClN3O8P2 - PubChem Can i take tramadol with hydroxychloroquine Structure, properties, spectra, suppliers and links for Chloroquine diphosphate, 50-63-5, Chloroquine Phosphate. Chloroquine diphosphate C18H32ClN3O8P2 ChemSpider. Chloroquine phosphate - Cayman Chemical. Chloroquine diphosphate salt - Sigma-Aldrich. Sigma-Aldrich offers a number of Chloroquine diphosphate salt products. View information & documentation regarding Chloroquine diphosphate salt, including CAS, MSDS & more. Chloroquine CQ is a lysosomotropic agent with an extensive range of biological effects 1. Historically known for its anti-malarial activity, chloroquine is a widely used biological research tool for studying autophagy inhibition. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH. Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes.