Visual fields in chloroquine

Discussion in 'Canadian Ed Drugstore' started by Art2004, 26-Feb-2020.

  1. Infodime XenForo Moderator

    Visual fields in chloroquine


    Plaquenil is less toxic than chloroquine; however, long-term use of either drug can result in macular toxicity, leading to devastating irreversible vision loss. The mechanism of this toxicity is not clearly understood, though it is believed that the drug molecule binds to melanin in the retinal pigment epithelium (RPE).

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    Use of Chloroquine phosphate tablets for indications other than acute malaria is contraindicated in the presence of retinal or visual field changes of any etiology. Use of Chloroquine phosphate tablets is contraindicated in patients with known hypersensitivity to 4-aminoquinoline compounds. Warnings. Chloroquine-Resistant Malaria Visual fields may be determined by several methods including a tangent screen, Goldmann perimeter, and computerized automated perimeters. Visual field examinations may be indicated in the diagnosis and monitoring visual field loss due to blepharoptosis or to disease involving the cornea, lens, retina, optic nerve, and intracranial visual pathway. In early cases of toxicity, visual fields will typically reveal a paracentral scotoma. If a 24-2 or 30-2 field is performed, be way of overlooking the 2-degree field of sparing seen on 10-2 fields; in these tests, a small central defect may be seen instead.

    Binding of the drug to melanin in the RPE contributes to, or prolongs, its toxic effects. This leads to disruption and damage to the photoreceptors and outer nuclear and plexiform layer, sparing the foveal center and resulting in the “bull’s eye” appearance in the late stage of the disease.

    Visual fields in chloroquine

    How to Succeed in Plaquenil Screenings, MEDICAL POLICY Visual Field Examination

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  4. Mar 04, 2014 Visual fields in a chloroquine treatment María del Carmen García-Domene,1,2 María Amparo Díez-Ajenjo,1,3 María Dolores de Fez,4 María José Luque2 1Fisabio Oftalmología Médica, València, 2Departament d'Òptica, Facultat de Física, Universitat de València, Burjassot, 3Clínica Optométrica Fundación Lluís Alcanyís, Valencia.

    • Full text Visual fields in a chloroquine treatment OPTO.
    • Hydroxychloroquine toxicity - EyeWiki.
    • Visual fields in a chloroquine treatment - CORE.

    Subjective testing of the central visual field was recommended to uncover early functional changes associated with paracentral scotomas. Paracentral scotomas have been reported prior to the associated maculopathy, so an amsler grid test or central 10-2 visual field perimetry was recommended. 2,5 Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says. Or, the visual field could just be patchy all over. If these errors are not too bad, the general gist of the field can be deduced, especially if compared to prior fields. Most often, as long as everything else is stable IOP, ONH appearance, we just reorder these fields in a few month’s time.

     
  5. agrigoriev New Member

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Treatment of morphea with hydroxychloroquine A. Your Baby, Jaundice and Phototherapy Drug-induced photosensitivity DermNet NZ
     
  6. Homat Well-Known Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Is it safe to take motrin and plaquenil together? Can You Take Other Pain Meds Along With Celebrex?
     
  7. Korefey XenForo Moderator

    Persistent cutaneous hyperpigmentation due to hydroxychloroquinone one. The few reports of bluish pigmentation with HCQ described resolution within a few months or did not specifiy the duration of pigmentation after discontinuation of the drug 4, 5, 6. Hydroxychloroquine is converted to an inactive metabolite in the liver and excreted in urine 25% in the active form and bile.

    Hydroxychloroquine DermNet NZ