Listing a study does not mean it has been evaluated by the U. The epidermal growth factor receptor (EGFR) signaling pathway plays a central role in the neoplastic transformation of NSCLC and promotes cancer cell survival, metastasis, and angiogenesis. Non-small cell lung cancer (NSCLC) is the most common cause of cancer mortality in men and women in Singapore. Hydroxychloroquine sulfate eye side effects Chloroquine blood plasma ratio As a lysosomotropic agent, hydroxychloroquine raises intralysosomal pH, impairing autophagic protein degradation; hydroxychloroquine-mediated accumulation of ineffective autophagosomes may result in cell death in tumor cells reliant on autophagy for survival. Autophagy and cancer. A large body of evidence suggests that the relationship between autophagy and cancer is complex.42, 43 On the one hand, autophagy appears to inhibit malignant transformation, reflecting its capability to limit the accumulation of potentially oncogenic entities like depolarized mitochondria which overproduce potentially genotoxic reactive oxygen species, ROS. Long-term hydroxychloroquine use has been associated with retinal toxicity, although patients with rheumatologic conditions often discontinue hydroxychloroquine therapy due to inadequate disease control rather than toxicity. Over the last three years, the FDA has approved two drugs for salvage treatment of NSCLC, gefitinib (Iressa ®, formerly known as ZD1839) and erlotinib (Tarceva ®, formerly known as OSI-774). The predominance of EGFR signaling in NSCLC makes the pathway an attractive candidate for the development of targeted therapeutics. Hydroxychloroquine lung cancer Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Chloroquine and hydroxychloroquine for cancer therapy Plaquenil retinopathy imagesHydroxychloroquine sulfate overdoseCan i drink alcohol while taking hydroxychloroquineStopping plaquenil effectsAralen Non–small-cell lung cancer NSCLC is the most common cause of cancer mortality in the United States 1 and chemotherapy is only modestly effective. A Phase I Study of Erlotinib and Hydroxychloroquine in Advanced Non.. Hydroxychloroquine Plaquenil Success, Reviews and Side.. Common and Rare Side Effects for Hydroxychloroquine Oral. Cancer plus an additional drug, hydroxychloroquine. The standard treatment for lung cancer. being used includes 2 chemotherapy drugs, called paclitaxel and carboplatin, plus a drug. that targets blood vessels, called bevacizumab also known as avastin. Hydroxychloroquine and Gefitinib to Treat Lung Cancer The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Patients with rheumatoid arthritis already have an increased risk of certain types of cancer, specifically lymphoma and lung cancer, likely as a result of their chronic inflammatory state.2. The patient has a 15-year history of rheumatoid arthritis, currently well controlled on hydroxychloroquine, methotrexate, and 7.5 mg daily of oral.