Regardless of the problem, we'd like to help you find what you're looking for. I've been taking Plaquenil 400 mg for nearly 6 mos. Chloroquine phosphate freshwater Long-term effects of taking plaquenil SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Muscle biopsy leads to a final diagnosis in most people with myositis. There are many causes of muscle weakness and pain more common than myositis, and testing for myositis is not a. Most patients presented with proximal muscle weakness. A wide range of treatment durations were noted from 4 days to 11 yrs with cumulative daily doses of 1.4 ± 0.96 mg. The toxicity became apparent in the majority of cases after changes in recent disease states such as decline in renal function, initiation of dialysis, or solid organ transplantation. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. Plaquenil and muscle weakness Hydroxychloroquine and Colchicine Induced Myopathy The Journal of., Myositis Symptoms and Causes - WebMD Plaquenil and folic acidChloroquine maculopathy treatmentPlaquenil discountPlaquenil and liver enzymes Plaquenil antibiotics are part of the fluoroquinolone antibiotics. Muscle weakness is a side effect. I would be very cautious! Quinolone antibiotics are chemotherapeutic and late side effects months to years later are common. Plaquenil weakness - Road Back Foundation. Hydroxychloroquine and Colchicine Induced Myopathy The.. Plaquenil vs. Aralen Prescription Treatment for Malaria.. Frequency not reported Skeletal muscle myopathy or neuromyopathy leading to progressive weakness and atrophy of proximal muscle groups, depression of tendon reflexes and abnormal nerve conduction studies. Myopathy may be reversible after therapy discontinuation, but recovery may take many months. Nervous system About a month ago, I finally decided to start taking the Plaquenil. I took 100 mg daily for a week since I'm highly sensitive to new medications, with the goal of reaching 400 mg daily after three weeks. One of my most bothersome symptoms is muscle weakness and fatigue, and the Plaquenil seemed to exacerbate it dramatically. This medicine may cause muscle and nerve problems. Check with your doctor right away if you have muscle weakness, pain, or tenderness while using this medicine. Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors.