Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Can plaquenil cause inflammation in my respiratory system Does plaquenil cause you to gain weight Taking plaquenil without food Plaquenil and diarrhea does it stop With Plaquenil, however, the most commonly prescribed anti-malarial, this sort of damage occurs only in 1 out of 5,000 people who take the drug for five years or more. For this reason though, it is important that you see an ophthalmologist for an exam before starting to take an anti-malarial medication for your lupus. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Incidence not known. Blistering, peeling, loosening of the skin. blurred vision or other vision changes. chest discomfort, pain, or tightness. cough or hoarseness. dark urine. decreased. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How long do side effects of plaquenil last Allergic reaction to plaquenil DailyStrength, Hydroxychloroquine Plaquenil Pain after stopping plaquenilChloroquine plus proguanilBest food for plaquenilChemical process of chloroquineAllergic to plaquenil SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Hydroxychloroquine Side Effects Common, Severe, Long Term.. Let me tell you what weaning down from Plaquenil is like.. When I increased to 200mg/day, I had strange side effects that caused me to go back to 100/day. Strange leg cramping, restless leg, nausea and anxiety. In a nutshell, at 200mg/day the side effects outweighed the benefits. At 100mg/day, I do not have 100% reduction in my symptoms, but I have enough of a reduction to want to continue the. Re Methotrexate vs Plaquenil side effects long term and short term The MTX dose for autoimmune disease is about 1/1000 the dose they use in cancer patients. MTX also has a long clinical history, which makes it a trustworthy drug, they'll be no "surprise" side effects. The crazy thing about this itching is that this is the 3rd attempt back on the plaquenil and with the 1st two tries I had no itching but different side effects that made me discontinue it. The 1st time I was on it brand name 400 mg. for 8 months and had to d/c due to terrible intestinal cramping and tinnitus.