First 4 weeks: 60 mg/m²/day or 2 mg/kg/day PO divided q8hr until urine is protein free for 3 consecutive days; not to exceed 28 days; dose not to exceed 80 mg/day Subsequent 4 weeks: 40 mg/m² or 1-1.5 mg/kg PO every other day; not to exceed 80 mg/day Maintenance in frequent relapses: 0.5-1 mg/kg/dose PO every other day for 3-6 months Treatment may have to be individualized Acne Adrenal suppression Delayed wound healing Diabetes mellitus GI perforation Glucose intolerance Hepatomegaly Hypokalemic alkalosis Increased transaminases Insomnia Menstrual irregularity Myopathy Neuritis Osteoporosis Peptic ulcer Perianal pruritus Pituitary adrenal axis suppression Pseudotumor cerebri (on withdrawal) Psychosis Seizure Ulcerative esophagitis Urticaria Vertigo Weight gain Documented hypersensitivity Systemic fungal infection, varicella, superficial herpes simplex keratitis Receipt of live or attenuated live vaccine; Advisory Committee on Immunization Practices (ACIP) and American Academy of Family Physicians (AAFP) state that administration of live virus vaccines usually is not contraindicated in patients receiving corticosteroid therapy as short-term ( Use with caution in cirrhosis, diabetes, ocular herpes simplex, hypertension, diverticulitis, following myocardial infarction, thyroid disease, seizure disorders, hypothyroidism, myasthenia gravis, hepatic impairment, peptic ulcer disease, osteoporosis, ulcerative colitis, psychotic tendencies, untreated systemic infections, renal insufficiency, pregnancy Thromboembolic disorders or myopathy may occur Delayed wound healing is possible Patients receiving corticosteroids should avoid chickenpox or measles-infected persons if unvaccinated Latent tuberculosis may be reactivated (patients with positive tuberculin test should be monitored) Some suggestion (not fully substantiated) of slightly increased cleft palate risk if corticosteroids are used in pregnancy Parenteral forms (prednisolone sodium phosphate) have been discontinued Suppression of hypothalamic-pituitary-adrenal axis may occur particularly in patients receiving high doses for prolonged periods or in young children; discontinuation of therapy should be done through slow taper Posterior subcapular cataract formation associated with prolonged use of corticosteroids Prolonged use of corticosteroids may increase risk of secondary infections Increase in intraocular pressure associated with prolonged use of corticosteroids Long-term use associated with fluid retention and hypertension Development of Kaposi's sarcoma associated with prolonged corticosteroid use Acute myopathy associated with high dose of corticosteroids Corticosteroid use may cause psychiatric disturbances If product is used for 10 days or longer, intraocular pressure should be routinely monitored even though it may be difficult in children and uncooperative patients; steroids should be used with caution in the presence of glaucoma. Intraocular pressure should be checked frequently Steroids after cataract surgery may delay healing and increase incidence of bleb formation Use of ocular steroids may prolong course and may exacerbate severity of many viral infections of the eye (including herpes simplex) Prednisolone shown to be teratogenic in mice when given in doses 1-10 times human dose; dexamethasone, hydrocortisone, and prednisolone were ocularly applied to both eyes of pregnant mice five times per day on days 10 through 13 of gestation; a significant increase in the incidence of cleft palate observed in fetuses of treated mice; there are no adequate well-controlled studies in pregnant women; prednisolone should be used during pregnancy only if potential benefit justifies potential risk to fetus Not known whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk; systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects Because of potential for serious adverse reactions in nursing infants from prednisolone, a decision should be made whether to discontinue nursing or to discontinue drug, taking into account importance of drug to mother Glucocorticosteroid; elicits mild mineralocorticoid activity and moderate anti-inflammatory effects; controls or prevents inflammation by controlling rate of protein synthesis, suppressing migration of polymorphonuclear leukocytes (PMNs) and fibroblasts, reversing capillary permeability, and stabilizing lysosomes at cellular level The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. The effects of GCs are widespread and include alterations in carbohydrates (increased blood glucose levels), stimulation of amino acid release, maintenance of fluid and electrolyte balance, preservation of normal cardiovascular system function, immune system suppression, and decreased bone formation. They should not be confused with muscle-building anabolic steroids (eg, testosterone). 8 Glucocorticoids (GCs), often referred to as corticosteroids, systemic steroids, or steroids, primarily are synthetic, biologically active derivatives of the cortisol secreted by the adrenal cortex. Indications GCs possess potent anti-inflammatory properties and are used to treat a variety of inflammatory and autoimmune disorders, placing them among the most frequently prescribed classes of drugs. In the United States, GCs are prescribed to 1 million patients per year, with approximately 2.5% of patients between the ages of 70 and 79 estimated as using them.1 Conditions commonly treated with steroids include asthma; arthritis (eg, rheumatoid arthritis); autoimmune disorders such as irritable bowel syndrome, lupus, and multiple sclerosis; skin conditions such as eczema and rashes; some types of cancer; and Addison’s disease (insufficient cortisol production) as well as the prevention of organ rejection in transplant recipients.2 Steroid Formulations The American Academy of Allergy, Asthma, and Immunology website provides useful online drug guides that include information on many of the most commonly available steroid products and formulations ( Oral formulations of steroids, such as prednisone (Deltasone), prednisolone (Prelone), dexamethasone (Decadron), and methylprednisolone (Medrol), typically are used to treat inflammation and pain associated with chronic conditions such as rheumatoid arthritis and lupus.3 Some steroids formulated for injection or IV infusion include methylprednisolone (Solu-Medrol) and dexamethasone (Dexasone). 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Generic Name: methylprednisolone (oral) (METH il pred NIS oh lone)Brand Names: Medrol, Medrol Dosepak, Methyl PREDNISolone Dose Pack Medically reviewed by Sanjai Sinha, MD. Methylprednisolone is a corticosteroid medicine that prevents the release of substances in the body that cause inflammation. Methylprednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders, and conditions that affect the skin, eyes, lungs, stomach, nervous system, or blood cells. Methylprednisolone may also be used for purposes not listed in this medication guide. You should not use this medicine if you have a fungal infection anywhere in your body. Before taking methylprednisolone, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids. Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Contrast Allergy Premed Pack with NDC 16129-101 is a a human prescription drug product labeled by Shertech Laboratories, Llc. The generic name of Contrast Allergy Premed Pack is prednisone, diphenhydramine. The product's dosage form is kit and is administered via form. Labeler Name: Product types are broken down into several potential Marketing Categories, such as NDA/ANDA/BLA, OTC Monograph, or Unapproved Drug. One and only one Marketing Category may be chosen for a product, not all marketing categories are available to all product types. Currently, only final marketed product categories are included. 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