She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Hydroxychloroquine cream side effects Trialnet hydroxychloroquine What is plaquenil therapy Chloroquine and parkinson's disease Apr 30 2013 by Theodore Leng, MD, MS Fundus autofluorescence from a 44-year-old woman with bilateral plaquenil toxicity. There is an area of hyperautofluorescence that corresponds to areas of outer retinal damage. Jun 11, 2009 The talc deposits range from 5 to 10 µm in size and are visualized as refractile yellow opacities in the macula. Ischemic sequelae include peripheral retinal or optic disk neovascularization, vitreous hemorrhage and arteriovenous anastomosis. Patients often present complaining of severe, progressive vision loss. The pathogenic effect of plaquenil is the induction of lysosomal dysfunction in photoreceptors and retinal pigment epithelium RPE cells. A lysosome is a membrane-bound organelle found in the cytoplasm of most cells and it contains hydrolytic enzymes that function in intracellular digestive processes. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Retinal deposits plaquenil infared imaging Miscellaneous - Retina Image Bank, Common Medications That May Be Toxic to the Retina Chloroquine omeprazoleAre mefloquine and plaquenil the sameChloroquine plus proguanil Oct 01, 2016 Fundus Autofluorescence in Retinal Disease A Review and Perspectives The second of a two-part series MADELINE YUNG, MD • DAVID SARRAF, MD. I n the first part of this series, which appeared in the last issue of Retinal Physician, we provided an overview of fundus autofluorescence FAF imaging technologies, and we reviewed the factors that produce and can affect fluorescence. Fundus Autofluorescence in Retinal Disease A Review and.. H35.381-383 Toxic Maculopathy Of Retina - Decision-Maker PLUS. TOXIC EFFECTS OF HYDROXYCHLOROQUINE ON THE CHOROID. RETINA. Conversely, in both normal adults and patients, we found many thickened structures that were undetect- able in visible wavelength light. To improve imaging of sub-retinal structures, we used infrared light, which passed readily into and out of the deeper fundus layers, with little visual consequence or pupil constriction Wyszecki & Stiles, 1982b. Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Plaquenil-induced toxicity usually will not occur before five years of. Retinal!toxicity.and!it!has!largely!replaced!chloroquine!as!a!treatment!ofinflammatory!disease. Unfortunately.the!retinal!damage!from!these!medications.