It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Chloroquine and piriton Does plaquenil change ph Treatment of uncomplicated malaria chloroquine Be sure to notify your other physicians that you are taking this drug. This drug does not have a strong effect on the immune system, so vaccines recommended by other physicians are generally acceptable. Be sure to notify your ophthalmologist that you are taking this Be sure to notify your other physicians when taking this drug. This drug does not have a strong effect on the immune system, so vaccines recommended by other physicians are generally acceptable. Notify your eye doctor when you are on this medication so regular visual screening tests can be performed. Basically, the immune system is a bit out of control. Plaquenil works by suppressing the immune system. Unfortunately you can't tell it to attack just the germs so you suppress all of its function to spare your healthy tissue- in your husband's case, his eyes, mouth, throat. NOTE Plaquinil and hydroxychloroquine are essentially the same drug. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Does plaquenil affect your immune system Hydroxychloroquine Plaquenil Side Effects & Dosage for., Hydroxychloroquine Plaquenil Plaquenil and ibdDying hair while taking plaquenilNatural medicine comparable to hydroxychloroquineHow to test chloroquine drug Mar 23, 2014 I doubt it is the Plaquenil affecting your immune system, but the actual Lupus itself as it can affects the white blood cells and lower them so we get every infection going. You need to speak to your rheumy for more clarification in your case. Plaquenil and immune system Lupus Forums at The Lupus Site. Do either hydroxychol/Plaquenil put you at risk for.. Taking Plaquenil for Rheumatoid Arthritis. Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Machanic on does hydroxychloroquine suppress the immune system been shown to affect the immune system. It tends to weaken it. I think you need to discuss this issue with your RD. Let him or her know you want some control, but not to make your immune system go permanently insane. I do think that Plaquenil is the mildest drug you can find. I think they all get stronger and more immune-suppressant from there, but I might be wrong! Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1.