Why malaria becomes resistant to chloroquine

Discussion in 'Canada Pharmacy Online' started by Andrey Malygin, 16-Mar-2020.

  1. seodigest New Member

    Why malaria becomes resistant to chloroquine


    Artemisinin Combination Therapies, or ACTs, are currently the frontline treatments against malaria. Although these treatments are working well in many parts of the world, there is serious concern that malaria parasites are once again developing widespread resistance to this vital treatment.

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    Malaria infection associated with travel. Center for Global Health Division of Parasitic Diseases and Malaria. Who can take chloroquine? Chloroquine can be prescribed to adults and children of all ages. It can also be safely taken by pregnant. women and nursing mothers. Who should not take chloroquine? People with psoriasis should not take. Plasmodium falciparum resistance to anti-malarial drugs remains a major obstacle to malaria control and elimination. The parasite has developed resistance to every anti-malarial drug introduced for wide-scale treatment. However, the spread of resistance may be reversible. Malawi was the first country to discontinue chloroquine use due to widespread resistance. Within a decade of the removal of. Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance.

    The cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. As the threat of antimalarial drug resistance grows, there is increasing pressure to sustain the efficacy of existing treatments, develop alternative treatments, as well putting in place preventative measures such as bednets.

    Why malaria becomes resistant to chloroquine

    CDC - Malaria - Malaria Worldwide - How Can Malaria Cases and Deaths Be., The return of chloroquine-susceptible Plasmodium falciparum malaria in.

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  4. Mar 19, 2020 Chloroquine, an old malaria drug, may help treat novel coronavirus, doctors say Chloroquine, or hydroxychloroquine, has been used to treat malaria since 1944.

    • Chloroquine, an old malaria drug, may help treat novel..
    • Chloroquine Resistance in Plasmodium falciparum Malaria..
    • Chloroquine Resistance in Malaria - ResearchGate.

    Both adults and children should take one dose of chloroquine per week starting at least 1 week before. traveling to the area where malaria transmission occurs. They should take one dose per week while there, and for 4 consecutive weeks after leaving. The weekly dosage for adults is 300mg base 500mg salt. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Are associated with chloroquine resistance, depending on the genetic background, and result in varying degrees of resistance 22, 24–26. However, the substitution of lysine to threonine at position 76 in pfcrt is found in all in vitro chloroquine-resistant parasites 27, 28. Although chloroquine resistance is a well-studied case

     
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  6. AlexeySeo New Member

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