If a patient is overweight, one should use the ideal body weight to assess whether the doaily dose is in the toxic range (/= 6.5 mg/kg/day). This graph shows various formulas that have been proposed for deriving ideal body weight for women, because virtually all cases of hydroxychloroquine toxicity have been female. Can plaquenil cause bone avascular Benefit of plaquenil Pros of chloroquine The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. For people who weigh less than 80 kg, a lower daily dose is prescribed, up to a maximum of 5 mg/kg of body weight. The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity 1. According to these new guidelines, the risk of HCQ retinal toxicity is less than 1 % in the first year of therapy and less than 2 % up to 10 years of therapy. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. As one can see, the height that corresponds to an ideal body weight of 135 pounds varies across the formulas. For this dosage, any woman with an ideal body weight less than 135 pounds would be in the toxic dose range. The usual hydroxychloroquine dose that is prescribed is 400 mg/day. Plaquenil dose based on weight Rx Side Effects New Plaquenil Guidelines and More - American Academy., New Guidelines on Hydroxychloroquine Dosage - Where Are We? - ACR. What does plaquenil do for sjogren& 39Plaquenil normal dosageCan i take metformin with hydrochloroquine Any concerns regarding dosage should be discussed with the prescribing physician. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. Plaquenil Risk Calculators. Ideal Body Weight for Calculating Hydroxychloroquine Dosage.. Plaquenil & Weight Gain/Loss -. The calculator can help guide clinicians toward a suggested weekly dosing schedule. It takes into account the patient’s weight and risk factors for Plaquenil retinopathy. With the weekly regimens, in some cases, the daily dose may exceed the 5mg/kg/day limit, but the weekly dose does not exceed 35mg/kg/week, the creators explain. Jan 03, 2020 Weight based dosage in adults and pediatric patients 13 mg/kg 10 mg/kg base, not to exceed 800 mg 620 mg base followed by 6.5 mg/kg 5 mg/kg base, not to exceed 400 mg 310 mg base, at 6 hours, 24 hours and 48 hours after the initial dose. PLAQUENIL film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. Adults. 200 mg 155 mg base to 400 mg 310 mg base PO per day, administered as a single dose or in 2 divided doses. Antimalarials and/or glucocorticoids are of benefit and may be used for the treatment of SLE without major organ manifestations; however, judicious use of hydroxychloroquine is recommended.