In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Can plaquenil cause decreased kidney function Can plaquenil cause numbness in tailbone area and legs Drowsiness hydroxychloroquine Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Hydroxychloroquine has significantly less retinal toxicity and has largely replaced chloroquine as a treatment of inflammatory disease. AT A GLANCE • Long-term use of hydroxychloroquine sulfate may result in parafoveal retinal toxicity. • No single imaging platform can confirm the presence of hydroxychloroquine toxicity. • Microperimetry and adaptive optics are undergoing studies to confirm their usefulness in. Plaquenil toxicity isn’t even in the top 10, or the top 100” if you’re looking at incidence, he said. “It’s a pretty rare thing.” Nevertheless, he urged doctors to master the Academy’s new guidelines, because the effects from chloroquine and hydroxychloroquine, when they do occur. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Retinal toxicity of hydroxychloroquine Determine risk for hydroxychloroquine retinal toxicity., Retina Today - Imaging in Hydroxychloroquine Toxicity April 2019 Affect of hydroxychloroquineHydroxychloroquine sarcoidosis hypercalcemiaPlaquenil and atenolol safe togetherAnyone has uti after taking f hydroxychloroquine A small percentage of patients exposed to hydroxychloroquine will develop irreversible, and potentially progressive, retinal toxicity for which no effective treatment exists. Objective changes typically precede complaints of visual loss. Retinal Physician - New Screening Guidelines for Hydroxychloroquine.. Rx Side Effects New Plaquenil Guidelines and More - American Academy.. Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine.. Retinal toxicity related to hydroxychloroquine in patients with systemic lupus erythematosus and rheumatoid arthritis. Telek HH, Yesilirmak N, Sungur G, Ozdemir Y, Yesil NK, Ornek F. Doc Ophthalmol. 2017 Dec; 1353187-194. Several studies have reported risk factors for hydroxychloroquine HCQ retinal toxicity, but data are limited for patients of Asian ancestry. The aim of this study was to investigate the rate of and factors for HCQ retinal toxicity in the Korean population. The Risk of Retinal Toxicity with Plaquenil. Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases.