Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil skin rash images Chloroquine dosage adult Chloroquine is a synthetic form of quinine, which has been used to treat malaria since the 1940s. Hydroxychloroquine shares a similar mechanism of action but is less toxic. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. A New Synthesis of Chloroquine Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria. Chloroquine synthetic The synthetic process used to make Chloroquine -, Chloroquine C18H26ClN3 - PubChem Adverse effects of hydroxychloroquine sulfate Chloroquine is a synthetic quinoline being used as an antimalaria and antirheumatoid agent. Several cases of hepatotoxicity have been reported with the use of chloroquine. However, the mechanisms of its hepatotoxic effect is unknown. The purpose of this study was to investigate the cytotoxic mechanism of chloroquine. Cytotoxicity of chloroquine in isolated rat hepatocytes.. A New Synthesis of Chloroquine Journal of the American.. What is chloroquine made out of? AnswersDrive. Chloroquine. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin chloroquine and Sontochin 3-methyl-chloroquine. These compounds belonged to a new class of antimalarials, the four-amino quinolines. Now that chloroquine is in the news everywhere, I thought it might be interesting to have a closer look at the compound. The first part of this post will be chemistry-heavy, further down we'll get into the pharmacology and medical uses. Chloroquine's fame is as an antimalarial drug, and the h The hydrochloride salt of chloroquine, a synthetic quinoline with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the.