Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Oct bull ey macula ellipsoid plaquenil Macular oct for plaquenil The maximum dose of Plaquenil is 6.5 mg/kg of ideal body weight per day, regardless of whether a person is overweight, underweight, or normal weight. One kilogram kg equals 2.2 pounds. Women with lupus who are OVER their ideal body weight should go by these dosing rules The patient’s height and weight are important factors in dosing the medication Experts recommend that daily doses be limited to 400 mg Hydroxychloroquine or 250mg Chloroquine Dosage levels that can cause toxicity 6.5 mg/kg Hydroxychloroquine Plaquenil19 3 mg/kg Chloroquine Arlen With Plaquenil Retinal damage from Plaquenil is extremely rare when doses do not exceed the maximum recommended which is about 3 mgs per lb/ 6.5 mgs per kilo of IDEAL body weight and when the patient has no liver or kidney problems. Since doses are cumulative the risk increases with time - 10 years is usually quoted. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil toxicity ideal body weight Early Plaquenil Toxicity Detected without Bull’s Eye., Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy Plaquenil side effects Previous reports indicate that toxicity is rare if dosing is less than 6.5 mg/kg/day. 2 To avoid overdosage, especially in obese patients or those of short stature, dose should be based on height, which allows for an estimation of ideal body weight. The drug clears slowly from the blood, so basing dosage on weight puts obese patients at risk. Hydroxychloroquine-Induced Retinal Toxicity - American.. Discontinued Plaquenil.other options?. Ideal Body Weight for Calculating Hydroxychloroquine.. The median weight was 160 pounds 72.7 kg, IQR 133, 185 pounds, range 90, 330 pounds. Twenty-nine percent of women were less than or equal to 63 inches tall 160 cm, a threshold height for potentially toxic dosing based on consumption of 400 mg hydroxychloroquine per day and a commonly used IBW algorithm. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Aug 30, 2011 A daily dose of 6.5mg/kg ideal body weight places patients at higher risk, but a daily dose below this level did not preclude the patient from developing toxicity after many years of treatment. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10.