I was told I didn't have to taper it like prednisone, and that I shouldn't expect any rebound type of reaction like you get when your body adjusts to being off pred. But everyone is taking a different mix of drugs and maybe you're taking something I don't that would make your doctor's recommendation for you different. Hydroxychloroquine common than Caffeine and plaquenil Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 With the Plaquenil I don't think you will find much relief in such a short time on it & at half of a workable dose. I have read about people stopping P & flaring up. Those who stopped it abruptly had real problems similar to what you are experiencing. If you really need to get off it, I would taper down slowly, very slowly. Again, I was surprised at how much relief I was getting and I noticed it almost immediately. The first time I did it was about 6 months after starting it because I didn't think it was doing anything for me. Turns out that the benefits come on so slowly that I didn't realize it was helping. Second time was maybe a year or so ago when I thought maybe I was getting a little better - and because of potential eye effects I thought I should try to eliminate it if possible. Abruptly stopping plaquenil Plaquenil Withdrawal – Life As An Anomaly, Rx Side Effects New Plaquenil Guidelines and More - American. Plaquenil show up on drug testChloroquine nursing considerationsHydroxychloroquine and chloroquine retinopathyU87 chloroquine in vivo Finally, my rheumatologist recommended that I stop taking the drug altogether.” Utterback’s rheumatologist also referred her to neuro-ophthalmologist David Katz, MD, in Bethesda, Md. “We don’t know which patients might develop Plaquenil retinopathy, but the patient often can see it before the doctor can,” he says. Protecting your eyesight when taking Plaquenil Lupus.. Hydroxychloroquine plaquenil withdrawl? - LUPUS UK. Plaquenil Hydroxychloroquine Side effects, Images, Uses.. Can I stop taking anti-malarials suddenly? Long-term anti-malarial use is normally safe. However, if you stop taking your anti-malarial drugs, you may experience a lupus flare. Potential added benefits of anti-malarial drugs. Anti-malarial drugs may have additional health benefits for some people. Plaquenil is a 6-weeker as far as the benefits are concerned, but it would be more dangerous to stop if you spend a lot of time outside and if this were the summer. If you're gonna experiment, I went off it cold turkey as it didn't hurt to do it that way, but you better get back on before the summer or you could experience a flare-up. I would assume from this that people had sudden and quite severe flares when stopping the plaquenil. There is always the chance that some people might interpret this as withdrawal, but I think it is probably always in the eye of the beholder. Hard to determine what other people are going through and not worth seeing who it right or wrong.